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- W207786671 abstract "Xenobiotic induced proliferation of peroxisomes in hepatic parenchymal cells of rats, mice and several other species is a unique biological phenomenon. Sustained peroxisome proliferation induced in the livers of rats and mice by several structurally unrelated non-mutagenic peroxisome proliferators leads to the development of altered hepatocyte foci, neoplastic nodules and hepatocellular carcinomas. Histological features and biological behaviour of peroxisome proliferator-induced hepatic lesions are essentially similar to those induced by classical genotoxic hepatocarcinogens. In the rat, peroxisome proliferator-induced preneoplastic and neoplastic lesions display some phenotypic properties such as resistance to iron accumulation, and decrease in the activities of glucose-6-phosphatase and adenosine triphosphatase, which are similar to those expressed in liver lesions induced by classical carcinogens. Despite these similarities, peroxisome proliferator-induced preneoplastic and neoplastic lesions in rat liver are phenotypically distinctly different from those induced by classical carcinogens in that these lesions do not express the activities of A-glutamyltranspeptidase and placental form of glutathione-S-transferase. This is due to the absence of these two proteins in liver nodules and hepatocellular carcinomas. In addition, the activities of phase II drug detoxifying enzymes are reduced in peroxisome proliferator-induced liver lesions. These differences suggest possible divergence in the mechanism by which non-mutagenic peroxisome proliferators and mutagenic classical carcinogens induce hepatocellular carcinomas." @default.
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- W207786671 title "Phenotypic Properties of Preneoplastic and Neoplastic Hepatic Lesions Induced by Peroxisome Proliferators in Rats" @default.
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