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- W2077874263 abstract "Background: Nuclear translocation is crucial for proper functioning of MAPKs.Results: Although most of MAPK Pmk1-driven functions are carried out independently of its presence into the nucleus, localization at this compartment allows down-regulation by phosphatases.Conclusion: Constitutive nuclear localization of Pmk1 is important to modulate its overall biological activity.Significance: These results highlight the relevance of the spatial control of MAPK activity. Background: Nuclear translocation is crucial for proper functioning of MAPKs. Results: Although most of MAPK Pmk1-driven functions are carried out independently of its presence into the nucleus, localization at this compartment allows down-regulation by phosphatases. Conclusion: Constitutive nuclear localization of Pmk1 is important to modulate its overall biological activity. Significance: These results highlight the relevance of the spatial control of MAPK activity." @default.
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- W2077874263 date "2012-07-01" @default.
- W2077874263 modified "2023-10-03" @default.
- W2077874263 title "Biological Significance of Nuclear Localization of Mitogen-activated Protein Kinase Pmk1 in Fission Yeast" @default.
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- W2077874263 doi "https://doi.org/10.1074/jbc.m112.345611" @default.
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