FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077875611> ?p ?o ?g. }

• W2077875611 endingPage "235" @default.
• W2077875611 startingPage "235" @default.
• W2077875611 abstract "Polyphenols in dietary and botanical matrices are usually present as simple and complex O-glycosides. In fermented dietary materials, the glycosidic moiety is removed and accompanied in some cases by more complex changes to the polyphenol. As for most xenobiotics, polyphenols undergo phase II conjugation in the intestinal wall during their absorption from the gut. In contrast, a few polyphenols, such as puerarin in the kudzu vine, are C-glycosides and are stable in the gut and during absorption, distribution and excretion. Large bowel bacteria reduce polyphenol aglycones, causing opening of the heterocyclic B-ring and ring cleavage. The products are mostly absorbed and enter the bloodstream. Phase I and II metabolism events occur in the intestine and the liver - most polyphenols predominantly circulate as β-glucuronides and sulfate esters with very little as the aglycones, the presumed active forms. In addition, metabolism can occur in non-hepatic tissues and cells including breast tumor cells that have variable amounts of cytochrome P450s, sulfatase and sulfotransferase activities. Inflammatory cells produce chemical oxidants (HOCl, HOBr, ONO(2)(-)) that will react with polyphenols. The isoflavones daidzein and genistein and the flavonol quercetin form mono- and dichlorinated products in reaction with HOCl. Genistein is converted to 3'-nitrogenistein in the lung tissue of lipopolysaccharide-treated rats. Whereas polyphenols that can be converted to quinones or epoxides react with glutathione (GSH) to form adducts, chlorinated isoflavones do not react with GSH; instead, they are converted to β-glucuronides and are excreted in bile. Analysis of polyphenols and their metabolites is routinely carried out with great sensitivity, specificity and quantification by LC-tandem mass spectrometry. Critical questions about the absorption and tissue uptake of complex polyphenols such as the proanthocyanins can be answered by labeling these polyphenols with (14)C-sucrose in plant cell culture and then purifying them for use in animal experiments. The (14)C signature is quantified using accelerator mass spectrometry, a technique capable of detecting one (14)C atom in 10(15) carbon atoms. This permits the study of the penetration of the polyphenols into the interstitial fluid, the fluid that is actually in contact with non-vascular cells." @default.
• W2077875611 created "2016-06-24" @default.
• W2077875611 creator A5001874713 @default.
• W2077875611 creator A5005860897 @default.
• W2077875611 creator A5011003263 @default.
• W2077875611 creator A5012098881 @default.
• W2077875611 creator A5024434331 @default.
• W2077875611 creator A5030239301 @default.
• W2077875611 creator A5044273464 @default.
• W2077875611 creator A5046682940 @default.
• W2077875611 creator A5072020842 @default.
• W2077875611 date "2011-01-01" @default.
• W2077875611 modified "2023-10-03" @default.
• W2077875611 title "The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems" @default.
• W2077875611 cites W1517210653 @default.
• W2077875611 cites W1535770459 @default.
• W2077875611 cites W1541220856 @default.
• W2077875611 cites W1832996211 @default.
• W2077875611 cites W1861891407 @default.
• W2077875611 cites W1872501806 @default.
• W2077875611 cites W1935573422 @default.
• W2077875611 cites W1963847375 @default.
• W2077875611 cites W1964016705 @default.
• W2077875611 cites W1970306797 @default.
• W2077875611 cites W1976881822 @default.
• W2077875611 cites W1979000874 @default.
• W2077875611 cites W1980953629 @default.
• W2077875611 cites W1983066852 @default.
• W2077875611 cites W1983496701 @default.
• W2077875611 cites W1984947705 @default.
• W2077875611 cites W1995173799 @default.
• W2077875611 cites W1998783744 @default.
• W2077875611 cites W2003424864 @default.
• W2077875611 cites W2003778744 @default.
• W2077875611 cites W2005469320 @default.
• W2077875611 cites W2011974113 @default.
• W2077875611 cites W2012297027 @default.
• W2077875611 cites W2013042117 @default.
• W2077875611 cites W2016002036 @default.
• W2077875611 cites W2022253832 @default.
• W2077875611 cites W2024828220 @default.
• W2077875611 cites W2026381068 @default.
• W2077875611 cites W2026789068 @default.
• W2077875611 cites W2027155648 @default.
• W2077875611 cites W2031379277 @default.
• W2077875611 cites W2034130022 @default.
• W2077875611 cites W2036252655 @default.
• W2077875611 cites W2049415617 @default.
• W2077875611 cites W2051185023 @default.
• W2077875611 cites W2053626025 @default.
• W2077875611 cites W2057390168 @default.
• W2077875611 cites W2063950428 @default.
• W2077875611 cites W2066718867 @default.
• W2077875611 cites W2068324242 @default.
• W2077875611 cites W2070588831 @default.
• W2077875611 cites W2073292063 @default.
• W2077875611 cites W2076999434 @default.
• W2077875611 cites W2078820962 @default.
• W2077875611 cites W2078959008 @default.
• W2077875611 cites W2084012701 @default.
• W2077875611 cites W2092254001 @default.
• W2077875611 cites W2094745968 @default.
• W2077875611 cites W2095571684 @default.
• W2077875611 cites W2107093217 @default.
• W2077875611 cites W2109173122 @default.
• W2077875611 cites W2114047846 @default.
• W2077875611 cites W2114379216 @default.
• W2077875611 cites W2114781822 @default.
• W2077875611 cites W2118089000 @default.
• W2077875611 cites W2119331100 @default.
• W2077875611 cites W2124104087 @default.
• W2077875611 cites W2124442181 @default.
• W2077875611 cites W2127137599 @default.
• W2077875611 cites W2128307360 @default.
• W2077875611 cites W2130481819 @default.
• W2077875611 cites W2136564303 @default.
• W2077875611 cites W2139388109 @default.
• W2077875611 cites W2142973990 @default.
• W2077875611 cites W2143408898 @default.
• W2077875611 cites W2144618543 @default.
• W2077875611 cites W2146619693 @default.
• W2077875611 cites W2160339017 @default.
• W2077875611 cites W2161803792 @default.
• W2077875611 cites W2163388941 @default.
• W2077875611 cites W2165266033 @default.
• W2077875611 cites W2166846320 @default.
• W2077875611 cites W2179801114 @default.
• W2077875611 cites W2185071301 @default.
• W2077875611 cites W2315748035 @default.
• W2077875611 cites W2327441694 @default.
• W2077875611 cites W4211180812 @default.
• W2077875611 cites W4240490760 @default.
• W2077875611 doi "https://doi.org/10.1039/c1fo10025d" @default.
• W2077875611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4122511" @default.
• W2077875611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21779561" @default.
• W2077875611 hasPublicationYear "2011" @default.
• W2077875611 type Work @default.
• W2077875611 sameAs 2077875611 @default.

• next