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- W2077875823 abstract "Within the sperm nucleus, the paternal genome remains functionally inert and protected following protamination. This is marked by a structural morphogenesis that is heralded by a striking reduction in nuclear volume. Despite these changes, both human and mouse spermatozoa maintain low levels of nucleosomes that appear non-randomly distributed throughout the genome. These regions may be necessary for organizing higher order genomic structure through interactions with the nuclear matrix. The promoters of this transcriptionally quiescent genome are differentially marked by modified histones that may poise downstream epigenetic effects. This notion is supported by increasing evidence that the embryo inherits these differing levels of chromatin organization. In concert with the suite of RNAs retained in the mature sperm, they may synergistically interact to direct early embryonic gene expression. Irrespective, these features reflect the transcriptional history of spermatogenic differentiation. As such, they may soon be utilized as clinical markers of male fertility. In this review, we explore and discuss how this may be orchestrated." @default.
- W2077875823 created "2016-06-24" @default.
- W2077875823 creator A5001635927 @default.
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- W2077875823 creator A5051876965 @default.
- W2077875823 creator A5073133239 @default.
- W2077875823 creator A5077555866 @default.
- W2077875823 date "2011-01-01" @default.
- W2077875823 modified "2023-10-14" @default.
- W2077875823 title "The sperm nucleus: chromatin, RNA, and the nuclear matrix" @default.
- W2077875823 cites W1487878375 @default.
- W2077875823 cites W1500224677 @default.
- W2077875823 cites W1527039926 @default.
- W2077875823 cites W1531014909 @default.
- W2077875823 cites W1537218255 @default.
- W2077875823 cites W1603817394 @default.
- W2077875823 cites W165264651 @default.
- W2077875823 cites W1802716950 @default.
- W2077875823 cites W1918118064 @default.
- W2077875823 cites W1949465845 @default.
- W2077875823 cites W1965783915 @default.
- W2077875823 cites W1967777775 @default.
- W2077875823 cites W1968418248 @default.
- W2077875823 cites W1970095805 @default.
- W2077875823 cites W1970561408 @default.
- W2077875823 cites W1972170164 @default.
- W2077875823 cites W1972439760 @default.
- W2077875823 cites W1972477951 @default.
- W2077875823 cites W1972607307 @default.
- W2077875823 cites W1973842956 @default.
- W2077875823 cites W1975859486 @default.
- W2077875823 cites W1976300935 @default.
- W2077875823 cites W1976822936 @default.
- W2077875823 cites W1982480043 @default.
- W2077875823 cites W1985098845 @default.
- W2077875823 cites W1988192567 @default.
- W2077875823 cites W1989462418 @default.
- W2077875823 cites W1989690233 @default.
- W2077875823 cites W1991136563 @default.
- W2077875823 cites W1992005194 @default.
- W2077875823 cites W1992493349 @default.
- W2077875823 cites W1992770121 @default.
- W2077875823 cites W1997632403 @default.
- W2077875823 cites W1998525496 @default.
- W2077875823 cites W2004271888 @default.
- W2077875823 cites W2006239074 @default.
- W2077875823 cites W2006866503 @default.
- W2077875823 cites W2007367058 @default.
- W2077875823 cites W2008978345 @default.
- W2077875823 cites W2010790480 @default.
- W2077875823 cites W2010868220 @default.
- W2077875823 cites W2018391507 @default.
- W2077875823 cites W2020653277 @default.
- W2077875823 cites W2024183626 @default.
- W2077875823 cites W2025676689 @default.
- W2077875823 cites W2025748382 @default.
- W2077875823 cites W2026670635 @default.
- W2077875823 cites W2029040687 @default.
- W2077875823 cites W2029357366 @default.
- W2077875823 cites W2029568007 @default.
- W2077875823 cites W2029601224 @default.
- W2077875823 cites W2033421234 @default.
- W2077875823 cites W2035074912 @default.
- W2077875823 cites W2036373513 @default.
- W2077875823 cites W2037108634 @default.
- W2077875823 cites W2037818631 @default.
- W2077875823 cites W2037863817 @default.
- W2077875823 cites W2040126142 @default.
- W2077875823 cites W2041482906 @default.
- W2077875823 cites W2041635443 @default.
- W2077875823 cites W2046874889 @default.
- W2077875823 cites W2047321973 @default.
- W2077875823 cites W2047638806 @default.
- W2077875823 cites W2047649140 @default.
- W2077875823 cites W2047683782 @default.
- W2077875823 cites W2047760682 @default.
- W2077875823 cites W2047939916 @default.
- W2077875823 cites W2049968571 @default.
- W2077875823 cites W2052710582 @default.
- W2077875823 cites W2053340213 @default.
- W2077875823 cites W2053508758 @default.
- W2077875823 cites W2055524075 @default.
- W2077875823 cites W2055883508 @default.
- W2077875823 cites W2057092823 @default.
- W2077875823 cites W2057691360 @default.
- W2077875823 cites W2057868893 @default.
- W2077875823 cites W2059710665 @default.
- W2077875823 cites W2060336856 @default.
- W2077875823 cites W2061487074 @default.
- W2077875823 cites W2061536881 @default.
- W2077875823 cites W2062536956 @default.
- W2077875823 cites W2063337177 @default.
- W2077875823 cites W2064358462 @default.
- W2077875823 cites W2065372697 @default.
- W2077875823 cites W2065984876 @default.
- W2077875823 cites W2068103782 @default.
- W2077875823 cites W2068991517 @default.