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- W2077875975 abstract "Mild cognitive impairment (MCI) is a heterogeneous risk factor for Alzheimer's Disease (AD), with some individuals progressing rapidly, others remaining stable for years, and some reverting to normal cognitive status. To determine whether a pattern of regional hypometabolism characteristic of AD can be identified and used to predict clinical decline and structural volume loss in MCI. Data from a subset of subjects from the AD Neuroimaging Initiative, including 51 normal controls (NC, mean age 75.9 ± 5.4 years, 28 M), 69 MCI (74.3 ± 7.5y; 55 M), and 38 probable AD (76.2 ± 6.6y; 23 M) were analyzed. A semi-automated procedure developed within the Morphometry Biomedical Informatics Research Network was used to quantify PET activity within individually-specific anatomical regions-of-interest (ROIs) defined on each subject's MRI. A linear discriminant function was trained on NC and AD data to identify a pattern of regional hypometabolism characteristic of AD then applied to MCI data. A pattern of hypometabolism in isthmus cingulate, mesial temporal, inferior parietal, and frontal ROIs best discriminated AD from NC. Figure 1 shows the percent difference in metabolism relative to NC for the AD group (Fig 1A) and the two MCI subgroups defined by application of the discriminant function to MCI data. The degree to which MCI individuals expressed the AD hypometabolic pattern was predictive of 1-year decline on the Mini Mental State Exam (r = 0.43 ; p < .001) and 1-year structural volume loss, as measured with quantitative MRI, in middle (r = 0.49 p = .002) and inferior (r = 0.48 p = .003) lateral temporal cortices. MCI subjects with phenotypic AD hypometabolism (Fig 1B) showed a significantly higher conversion rate to probable AD (9/30) than did those showing the NC metabolic phenotype (Fig 1C; 1/39) (p = .002). Patterns of regional hypometabolism at baseline are predictive of 1-year clinical decline and structural volume loss in individuals with MCI. These results suggest that PET measures may be of value for individual patient prognosis and for increasing the efficiency of large-scale clinical trials. Supported by: Morphometry BIRN U24-RR021382; ADNI U01-AG024904." @default.
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- W2077875975 date "2008-07-01" @default.
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- W2077875975 title "P2-051: Regional metabolism in mild cognitive impairment predicts clinical decline and structural volume loss: Initial results from the Alzheimer's disease neuroimaging initiative (ADNI)" @default.
- W2077875975 doi "https://doi.org/10.1016/j.jalz.2008.05.1124" @default.
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