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- W2077877356 abstract "1 . A method is described for measuring continuously the efflux of potassium or rubidium from smooth muscle of the guinea-pig. 2 . Muscarinic drugs cause at maximum a 100-fold increase in the efflux rate, due to a direct increase in permeability and only to a minor extent secondary to depolarization. With acetylcholine the dose response curve for producing efflux is displaced to 1,000 times higher concentrations than that for contraction. 3 . The shift varies with different agonists. The efflux and contractile responses to agonists are antagonized to an equivalent extent by atropine and several other reversible antagonists but benzhexol has a relatively greater effect on efflux. An estimate of spare receptors was obtained with benzilylcholine mustard and was similar for both responses. Dibenamine and local anaesthetics led to a parallel shift of the contraction dose response curve but a depression without shift in the efflux response. 4 . The most satisfactory explanation of these results is that there are two types of the muscarinic receptor in the smooth muscle of the guinea-pig intestine." @default.
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- W2077877356 date "1997-02-01" @default.
- W2077877356 modified "2023-10-17" @default.
- W2077877356 title "The action of acetylcholine and other drugs on the efflux of potassium and rubidium from smooth muscle of the guinea-pig intestine" @default.
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- W2077877356 doi "https://doi.org/10.1111/j.1476-5381.1997.tb06813.x" @default.
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