Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077877504> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2077877504 endingPage "954" @default.
- W2077877504 startingPage "947" @default.
- W2077877504 abstract "The absorption, metabolism and excretion of orally administered 14C-labelled amaranth has been studied in the rat, mouse and guinea-pig. Following administration of a single oral dose of either 2 or 200 mg/kg, most of the radioactivity was excreted in the urine and faeces in the first 24 hr, and substantially all of the dose was recovered in the excreta within 72 hr. In the rat and mouse, the principal route of excretion was the faeces, whereas in the guinea-pig, urinary excretion accounted for up to 50% of the dose. In the rat and guinea-pig the proportion of the dose excreted in the urine was significantly greater at the lower dose level. No marked accumulation of radioactivity was found in any tissues 72 hr after the administration of the labelled colouring. For all three species most of the radioactivity was shown to be associated with naphthionic acid, with traces of unchanged amaranth and a number of other unidentified metabolites also being detected. In the rat and mouse substantially all of the remaining radioactivity was associated with a single unidentified component. Naphthionic acid was found in the faeces of all three species along with a substantial, but variable, amount of unchanged dye. At least six other radioactive peaks were seen in the chromatograms of faecal extracts; two of these peaks had similar chromatographic properties to the unknown metabolites in the urine, but there was no peak corresponding to 1-amino-2-naphthol-3,6-disulphonic acid (1-ANDSA), previously reported as a urinary metabolite of amaranth. In studies of absorption from isolated loops of small intestine of the rat, mouse and guinea-pig, no significant absorption of amaranth was detected over a 100-fold concentration range (20-2000 ppm)." @default.
- W2077877504 created "2016-06-24" @default.
- W2077877504 creator A5057953562 @default.
- W2077877504 creator A5063512149 @default.
- W2077877504 creator A5075754659 @default.
- W2077877504 creator A5082936052 @default.
- W2077877504 creator A5087274226 @default.
- W2077877504 date "1987-12-01" @default.
- W2077877504 modified "2023-09-25" @default.
- W2077877504 title "Metabolic disposition of 14C-labelled amaranth in the rat, mouse and guinea-pig" @default.
- W2077877504 cites W1966993940 @default.
- W2077877504 cites W1974274005 @default.
- W2077877504 cites W2023404272 @default.
- W2077877504 cites W2038854296 @default.
- W2077877504 cites W2039581557 @default.
- W2077877504 cites W2043259360 @default.
- W2077877504 cites W2054370993 @default.
- W2077877504 cites W2064978480 @default.
- W2077877504 cites W2074569726 @default.
- W2077877504 cites W2076078833 @default.
- W2077877504 cites W2089110422 @default.
- W2077877504 cites W2121613455 @default.
- W2077877504 cites W2163142467 @default.
- W2077877504 cites W2166769912 @default.
- W2077877504 cites W2333879153 @default.
- W2077877504 cites W4237307789 @default.
- W2077877504 cites W4245862039 @default.
- W2077877504 doi "https://doi.org/10.1016/0278-6915(87)90288-2" @default.
- W2077877504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3692402" @default.
- W2077877504 hasPublicationYear "1987" @default.
- W2077877504 type Work @default.
- W2077877504 sameAs 2077877504 @default.
- W2077877504 citedByCount "8" @default.
- W2077877504 countsByYear W20778775042017 @default.
- W2077877504 crossrefType "journal-article" @default.
- W2077877504 hasAuthorship W2077877504A5057953562 @default.
- W2077877504 hasAuthorship W2077877504A5063512149 @default.
- W2077877504 hasAuthorship W2077877504A5075754659 @default.
- W2077877504 hasAuthorship W2077877504A5082936052 @default.
- W2077877504 hasAuthorship W2077877504A5087274226 @default.
- W2077877504 hasConcept C10146269 @default.
- W2077877504 hasConcept C121332964 @default.
- W2077877504 hasConcept C125287762 @default.
- W2077877504 hasConcept C126322002 @default.
- W2077877504 hasConcept C134018914 @default.
- W2077877504 hasConcept C185592680 @default.
- W2077877504 hasConcept C24890656 @default.
- W2077877504 hasConcept C2778815084 @default.
- W2077877504 hasConcept C2780026642 @default.
- W2077877504 hasConcept C2781052702 @default.
- W2077877504 hasConcept C43617362 @default.
- W2077877504 hasConcept C55493867 @default.
- W2077877504 hasConcept C61716771 @default.
- W2077877504 hasConcept C62231903 @default.
- W2077877504 hasConcept C71924100 @default.
- W2077877504 hasConcept C77411442 @default.
- W2077877504 hasConcept C86803240 @default.
- W2077877504 hasConcept C89423630 @default.
- W2077877504 hasConceptScore W2077877504C10146269 @default.
- W2077877504 hasConceptScore W2077877504C121332964 @default.
- W2077877504 hasConceptScore W2077877504C125287762 @default.
- W2077877504 hasConceptScore W2077877504C126322002 @default.
- W2077877504 hasConceptScore W2077877504C134018914 @default.
- W2077877504 hasConceptScore W2077877504C185592680 @default.
- W2077877504 hasConceptScore W2077877504C24890656 @default.
- W2077877504 hasConceptScore W2077877504C2778815084 @default.
- W2077877504 hasConceptScore W2077877504C2780026642 @default.
- W2077877504 hasConceptScore W2077877504C2781052702 @default.
- W2077877504 hasConceptScore W2077877504C43617362 @default.
- W2077877504 hasConceptScore W2077877504C55493867 @default.
- W2077877504 hasConceptScore W2077877504C61716771 @default.
- W2077877504 hasConceptScore W2077877504C62231903 @default.
- W2077877504 hasConceptScore W2077877504C71924100 @default.
- W2077877504 hasConceptScore W2077877504C77411442 @default.
- W2077877504 hasConceptScore W2077877504C86803240 @default.
- W2077877504 hasConceptScore W2077877504C89423630 @default.
- W2077877504 hasIssue "12" @default.
- W2077877504 hasLocation W20778775041 @default.
- W2077877504 hasLocation W20778775042 @default.
- W2077877504 hasOpenAccess W2077877504 @default.
- W2077877504 hasPrimaryLocation W20778775041 @default.
- W2077877504 hasRelatedWork W1990339146 @default.
- W2077877504 hasRelatedWork W2009246547 @default.
- W2077877504 hasRelatedWork W2044886606 @default.
- W2077877504 hasRelatedWork W2045937169 @default.
- W2077877504 hasRelatedWork W2077877504 @default.
- W2077877504 hasRelatedWork W2080675292 @default.
- W2077877504 hasRelatedWork W2081707388 @default.
- W2077877504 hasRelatedWork W2086777583 @default.
- W2077877504 hasRelatedWork W2139038320 @default.
- W2077877504 hasRelatedWork W2416147863 @default.
- W2077877504 hasVolume "25" @default.
- W2077877504 isParatext "false" @default.
- W2077877504 isRetracted "false" @default.
- W2077877504 magId "2077877504" @default.
- W2077877504 workType "article" @default.