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- W2077878434 abstract "RESULTS: No significant difference was noted in 5-year CSS between GC NAC (58%) and non-NAC cohorts (61%). The median followup was 19.6 months for GC NAC and 106.5 months for non-NAC. Patients with residual non-muscle-invasive disease (pTis, pTa, pT1) after GC NAC exhibit similar 5-year CSS relative to patients with no residual carcinoma (pT0), p1⁄40.99. NAC pathologic responders ( T1, n1⁄480) demonstrated improved 5-year CSS rates of 90.6% vs. 27.1% (p<0.01) and decreased nodal positivity rates of 0% vs. 41.3% (p<0.01) compared to NAC pathologic non-responders ( pT2). Clinical and pathologic outcomes were inferior in NAC pathologic non-responders compared to the entire RC only treated cohort (pT2-T4). A significantly lower pathologic non-response rate was seen in those able to tolerate sufficient dosing of NAC when patients were stratified by the JHH-DI (p1⁄40.049) which is congruent with NCCN guidelines. A multivariate decision tree model demonstrated age 60 years and clinical stage cT2 as significant of response to NAC (p<0.05). CONCLUSIONS: Pathologic non-responders fare worse than patients proceeding directly to RC alone, suggesting the need to identify clinical features predictive of poor response prior to the initiation of chemotherapy. To this effect, multiple predictive models incorporating clinical, histopathologic, and molecular features are currently being developed to identify patients, prior to the initiation of therapy, that are most likely to benefit or not benefit from GC NAC." @default.
- W2077878434 created "2016-06-24" @default.
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- W2077878434 date "2015-04-01" @default.
- W2077878434 modified "2023-09-25" @default.
- W2077878434 title "MP72-09 ADJUVANT CISPLATIN LEADS TO A LARGER DECLINE IN GFR THAN NEOADJUVANT CISPLATIN IN RADICAL CYSTECTOMY PATIENTS" @default.
- W2077878434 doi "https://doi.org/10.1016/j.juro.2015.02.2643" @default.
- W2077878434 hasPublicationYear "2015" @default.
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