FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077880010> ?p ?o ?g. }

• W2077880010 endingPage "45" @default.
• W2077880010 startingPage "41" @default.
• W2077880010 abstract "Previous studies demonstrated that nuclear factor κB (NF-κB) activation is decreased in dorsal root ganglia (DRG) of rats having streptozotocin (STZ)-induced diabetes. DRG contain cell bodies of neurons that convey sensory signals from the periphery. To determine the relationship between diabetes-induced neuropathy and NF-κB expression in DRG, behavioral, immunohistochemical, and biochemical studies were performed on naïve and 3-month diabetic rats. Behavioral studies confirmed that many diabetic rats develop tactile allodynia, or increased sensitivity to light touch, in the hind paws. Immunohistochemical studies on lumbar DRG that receive input from the affected regions revealed that p50 and p65, frequent NF-κB subunit partners, are differentially localized. Intense p65 immunostaining was detected in the cytoplasm of small- and medium-sized neurons as well as in satellite cells. In contrast, p50 was localized in the cytoplasm of virtually all neurons. In many cases, prominent staining was also present in nuclei, a location consistent with transcription factor activation. Immunohistochemical and biochemical studies found that the nuclear to cytoplasmic ratio of p50 expression was significantly reduced in diabetic rats compared to that in naïve animals. Our findings raise the possibility that changes in NF-κB activation in a subset of DRG neurons participates in mediating diabetes-induced sensory neuropathy." @default.
• W2077880010 created "2016-06-24" @default.
• W2077880010 creator A5003935246 @default.
• W2077880010 creator A5010941476 @default.
• W2077880010 creator A5064834050 @default.
• W2077880010 creator A5076643227 @default.
• W2077880010 creator A5090742890 @default.
• W2077880010 date "2011-02-01" @default.
• W2077880010 modified "2023-09-26" @default.
• W2077880010 title "NF-κB subunits are differentially distributed in cells of lumbar dorsal root ganglia in naïve and diabetic rats" @default.
• W2077880010 cites W1491068335 @default.
• W2077880010 cites W1970510419 @default.
• W2077880010 cites W1976897228 @default.
• W2077880010 cites W1992524499 @default.
• W2077880010 cites W2001476096 @default.
• W2077880010 cites W2003404396 @default.
• W2077880010 cites W2004844172 @default.
• W2077880010 cites W2006770050 @default.
• W2077880010 cites W2008814047 @default.
• W2077880010 cites W2011496352 @default.
• W2077880010 cites W2015518484 @default.
• W2077880010 cites W2024830579 @default.
• W2077880010 cites W2037491362 @default.
• W2077880010 cites W2050369461 @default.
• W2077880010 cites W2050765595 @default.
• W2077880010 cites W2052908553 @default.
• W2077880010 cites W2057710663 @default.
• W2077880010 cites W2058530681 @default.
• W2077880010 cites W2065021154 @default.
• W2077880010 cites W2069416236 @default.
• W2077880010 cites W2086697238 @default.
• W2077880010 cites W2087296641 @default.
• W2077880010 cites W2091720251 @default.
• W2077880010 cites W2116522904 @default.
• W2077880010 cites W2128916701 @default.
• W2077880010 cites W2139012911 @default.
• W2077880010 cites W2148119611 @default.
• W2077880010 cites W2166711075 @default.
• W2077880010 cites W2222470717 @default.
• W2077880010 cites W4240799972 @default.
• W2077880010 cites W4251712623 @default.
• W2077880010 doi "https://doi.org/10.1016/j.neulet.2010.12.022" @default.
• W2077880010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4079108" @default.
• W2077880010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21167912" @default.
• W2077880010 hasPublicationYear "2011" @default.
• W2077880010 type Work @default.
• W2077880010 sameAs 2077880010 @default.
• W2077880010 citedByCount "11" @default.
• W2077880010 countsByYear W20778800102012 @default.
• W2077880010 countsByYear W20778800102013 @default.
• W2077880010 countsByYear W20778800102015 @default.
• W2077880010 countsByYear W20778800102017 @default.
• W2077880010 countsByYear W20778800102018 @default.
• W2077880010 countsByYear W20778800102019 @default.
• W2077880010 countsByYear W20778800102020 @default.
• W2077880010 countsByYear W20778800102021 @default.
• W2077880010 crossrefType "journal-article" @default.
• W2077880010 hasAuthorship W2077880010A5003935246 @default.
• W2077880010 hasAuthorship W2077880010A5010941476 @default.
• W2077880010 hasAuthorship W2077880010A5064834050 @default.
• W2077880010 hasAuthorship W2077880010A5076643227 @default.
• W2077880010 hasAuthorship W2077880010A5090742890 @default.
• W2077880010 hasBestOaLocation W20778800102 @default.
• W2077880010 hasConcept C105702510 @default.
• W2077880010 hasConcept C126322002 @default.
• W2077880010 hasConcept C134018914 @default.
• W2077880010 hasConcept C142724271 @default.
• W2077880010 hasConcept C169760540 @default.
• W2077880010 hasConcept C190062978 @default.
• W2077880010 hasConcept C204232928 @default.
• W2077880010 hasConcept C2776281502 @default.
• W2077880010 hasConcept C2779280383 @default.
• W2077880010 hasConcept C4224716 @default.
• W2077880010 hasConcept C44575665 @default.
• W2077880010 hasConcept C555293320 @default.
• W2077880010 hasConcept C71924100 @default.
• W2077880010 hasConcept C86803240 @default.
• W2077880010 hasConcept C94487597 @default.
• W2077880010 hasConcept C95444343 @default.
• W2077880010 hasConceptScore W2077880010C105702510 @default.
• W2077880010 hasConceptScore W2077880010C126322002 @default.
• W2077880010 hasConceptScore W2077880010C134018914 @default.
• W2077880010 hasConceptScore W2077880010C142724271 @default.
• W2077880010 hasConceptScore W2077880010C169760540 @default.
• W2077880010 hasConceptScore W2077880010C190062978 @default.
• W2077880010 hasConceptScore W2077880010C204232928 @default.
• W2077880010 hasConceptScore W2077880010C2776281502 @default.
• W2077880010 hasConceptScore W2077880010C2779280383 @default.
• W2077880010 hasConceptScore W2077880010C4224716 @default.
• W2077880010 hasConceptScore W2077880010C44575665 @default.
• W2077880010 hasConceptScore W2077880010C555293320 @default.
• W2077880010 hasConceptScore W2077880010C71924100 @default.
• W2077880010 hasConceptScore W2077880010C86803240 @default.
• W2077880010 hasConceptScore W2077880010C94487597 @default.
• W2077880010 hasConceptScore W2077880010C95444343 @default.
• W2077880010 hasIssue "1" @default.
• W2077880010 hasLocation W20778800101 @default.
• W2077880010 hasLocation W20778800102 @default.

• next