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- W2077881308 abstract "Xotch is a Xenopus homolog of Notch, a receptor involved in cell fate decisions in Drosophila. Using an extracellular deletion construct, Xotch delta E, we show that Xotch has a similar role in Xenopus embryos. Broad expression causes the loss of dorsal structures and the expansion and disorganization of the brain. Single blastomere injections of Xotch delta E induce autonomous neural and mesodermal hypertrophy, even in the absence of cell division. Xotch delta E inhibits the early expression of epidermal and neural crest markers yet enhances and extends the response of animal caps to mesodermal and neural induction. Our data suggest a mechanism for the function of Notch homologs in which they delay differentiation and leave undetermined cells competent to respond to later inductive signals." @default.
- W2077881308 created "2016-06-24" @default.
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- W2077881308 date "1993-05-01" @default.
- W2077881308 modified "2023-09-24" @default.
- W2077881308 title "Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos" @default.
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- W2077881308 doi "https://doi.org/10.1016/0092-8674(93)90247-n" @default.
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