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- W2077881951 abstract "Several strobilurin fungicides inhibiting fungal respiration by binding to cytochrome b have been introduced recently. A mechanism of strobilurin resistance identified as active in several plant pathogenic fungi is based on the activation of alternative respiration. Thus far, respective studies have been restricted to single isolates of respective pathogens. Here, we report a study on 250 Venturia inaequalis baseline isolates to the strobilurin kresoxim-methyl having a broad sensitivity distribution characterized by a 50-fold difference in sensitivity of the most- and least-sensitive isolates. For the majority (62%) of these isolates, differences in sensitivity were not caused by the interference of alternative respiration with the full inhibitory potency of kresoxim-methyl. Rather, variable dose-responses with largely different degrees of inhibition achieved at a low dose of kresoxim-methyl were found to be responsible. For 38% of the baseline isolates, alternative respiration was already active during the stage of conidia germination. Activation of this pathway was, again, dependent on the strobilurin dose. Selection of sub-populations of isolates resisting low doses of kresoxim-methyl by multiple mechanisms and the recombination among isolates expressing such mechanisms singly can be expected to be slowed by an anti-resistance strategy based on high strobilurin doses. © 1999 Society of Chemical Industry" @default.
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- W2077881951 date "1999-10-15" @default.
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- W2077881951 title "Diversity of kresoxim-methyl sensitivities in baseline populations of<i>Venturia inaequalis</i>" @default.
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- W2077881951 doi "https://doi.org/10.1002/(sici)1096-9063(199911)55:11<1083::aid-ps68>3.0.co;2-u" @default.
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