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• W2077881967 abstract "The main objective of this research is to design a new extended release multiparticulate delivery system by incorporation into nanoparticles made of chitosan-polymethacrylic acid copolymers. As the first part of a continued research on conversion of chitosan to useful biopolymer-based materials, by grafting polymethacrylic acid (PMAA), free radical graft copolymerization was carried out at 70 °C, with bis-acrylamide as a cross-linking agent and persulfate as an initiator. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids. Also, the paclitaxel as a model drug was entrapped in these nano-gels and in vitro release profiles were established separately in both enzyme-free SGF and SIF. The drug release was found to be faster in SIF." @default.
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• W2077881967 date "2010-09-01" @default.
• W2077881967 modified "2023-10-16" @default.
• W2077881967 title "Design and characterization of chitosan nanoparticles as delivery systems for paclitaxel" @default.
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• W2077881967 doi "https://doi.org/10.1016/j.carbpol.2010.05.005" @default.
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