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- W2077885464 abstract "A genome-wide location analysis method has been introduced as a means to simultaneously study protein-DNA binding interactions for a large number of genes on a microarray platform. Identification of interactions between transcription factors (TF) and genes provide insight into the mechanisms that regulate a variety of cellular responses. Drawing proper inferences from the experimental data is key to finding statistically significant TF-gene binding interactions. We describe how the analysis and interpretation of genome-wide location data can be fit into a traditional statistical modeling framework that considers the data across all arrays and formulizes appropriate hypothesis tests. The approach is illustrated with data from a yeast transcription factor binding experiment that illustrates how identified TF-gene interactions can enhance initial exploration of transcriptional regulatory networks. Examples of five kinds of transcriptional regulatory structure are also demonstrated. Some stark differences with previously published results are explored." @default.
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- W2077885464 date "2004-01-29" @default.
- W2077885464 modified "2023-09-23" @default.
- W2077885464 title "A Mixed Model Approach to Identify Yeast Transcriptional Regulatory Motifs via Microarray Experiments" @default.
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- W2077885464 doi "https://doi.org/10.2202/1544-6115.1045" @default.
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