Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077886558> ?p ?o ?g. }
- W2077886558 abstract "Mitogen/extracellular signal-regulated kinase kinase-5 (MEK5), which belongs to a network of mitogen-activated protein kinase pathways, play a pivotal role in carcinogenesis. The purpose of this study was to investigate whether variants in the MEK5 gene promoter were involved in susceptivity of individuals to sporadic colorectal cancer (CRC). In the present hospital-based case-control study of 737 patients with sporadic CRC and 703 healthy control subjects in a southern Chinese population, the two polymorphisms of MEK5 promoter (i.e., rs7172582C>T and rs3743354T>C) were genotyped by TaqMan assay. There were significant differences between cases and controls in the genotype and allele distribution of the MEK5 gene rs3743354T>C polymorphism. The rs3743354 CC genotype was associated with a significantly decreased risk of CRC when compared with the TT genotype (adjusted odds ratios [ORs]=0.43; 95% confidence interval [CI], 0.24-0.77). Compared to the T allele, a significant correlation was detected between the presence of the C allele and decreased risk of CRC (adjusted OR=0.79; 95% CI, 0.61-0.94). The decreased risk of CRC associated with rs3743354 variant genotypes (i.e., CT+CC) was found in the smoker subgroup (adjusted OR=0.63; 95% CI=0.45-0.88). Further, environmental factors, including smoking and drinking, interacted with rs3743354C variant genotypes to reduce CRC risk. Western blot analysis showed that the levels of MEK5 protein in sporadic CRC neoplastic tissues and adjacent normal colorectal epithelium tissues were lower in the carriers of rs3743354 CC genotypes than that in those with rs3743354 TT genotypes or those with rs3743354 TC genotypes. However, no significant association was found between the rs7172582C>T polymorphism and risk of CRC. These data indicate that the rs3743354 polymorphism in the MEK5 promoter may affect the risk of developing CRC." @default.
- W2077886558 created "2016-06-24" @default.
- W2077886558 creator A5004838110 @default.
- W2077886558 creator A5015158690 @default.
- W2077886558 creator A5017604936 @default.
- W2077886558 creator A5026898912 @default.
- W2077886558 creator A5042099213 @default.
- W2077886558 creator A5051005701 @default.
- W2077886558 creator A5073216396 @default.
- W2077886558 creator A5074310982 @default.
- W2077886558 creator A5089606475 @default.
- W2077886558 date "2012-03-01" @default.
- W2077886558 modified "2023-09-27" @default.
- W2077886558 title "Mitogen/Extracellular Signal-Regulated Kinase Kinase-5 Promoter Region Polymorphisms Affect the Risk of Sporadic Colorectal Cancer in a Southern Chinese Population" @default.
- W2077886558 cites W1627448887 @default.
- W2077886558 cites W1965116430 @default.
- W2077886558 cites W1965338159 @default.
- W2077886558 cites W1965734230 @default.
- W2077886558 cites W1968613607 @default.
- W2077886558 cites W1969608756 @default.
- W2077886558 cites W1972511274 @default.
- W2077886558 cites W1977304081 @default.
- W2077886558 cites W1982673296 @default.
- W2077886558 cites W1986114812 @default.
- W2077886558 cites W1987101107 @default.
- W2077886558 cites W2015641814 @default.
- W2077886558 cites W2016511595 @default.
- W2077886558 cites W2025732015 @default.
- W2077886558 cites W2027929872 @default.
- W2077886558 cites W2030284600 @default.
- W2077886558 cites W2040912028 @default.
- W2077886558 cites W2049128986 @default.
- W2077886558 cites W2053841000 @default.
- W2077886558 cites W2070717171 @default.
- W2077886558 cites W2080327105 @default.
- W2077886558 cites W2094810771 @default.
- W2077886558 cites W2096925894 @default.
- W2077886558 cites W2097367999 @default.
- W2077886558 cites W2108172198 @default.
- W2077886558 cites W2109838780 @default.
- W2077886558 cites W2111225835 @default.
- W2077886558 cites W2119541125 @default.
- W2077886558 cites W2121245276 @default.
- W2077886558 cites W2134468110 @default.
- W2077886558 cites W2137000540 @default.
- W2077886558 cites W2139098554 @default.
- W2077886558 cites W2158457654 @default.
- W2077886558 cites W2165494254 @default.
- W2077886558 cites W2165693726 @default.
- W2077886558 cites W2369381620 @default.
- W2077886558 cites W2396509159 @default.
- W2077886558 cites W2524566873 @default.
- W2077886558 doi "https://doi.org/10.1089/dna.2011.1232" @default.
- W2077886558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3300074" @default.
- W2077886558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21861603" @default.
- W2077886558 hasPublicationYear "2012" @default.
- W2077886558 type Work @default.
- W2077886558 sameAs 2077886558 @default.
- W2077886558 citedByCount "4" @default.
- W2077886558 countsByYear W20778865582012 @default.
- W2077886558 countsByYear W20778865582013 @default.
- W2077886558 countsByYear W20778865582016 @default.
- W2077886558 countsByYear W20778865582021 @default.
- W2077886558 crossrefType "journal-article" @default.
- W2077886558 hasAuthorship W2077886558A5004838110 @default.
- W2077886558 hasAuthorship W2077886558A5015158690 @default.
- W2077886558 hasAuthorship W2077886558A5017604936 @default.
- W2077886558 hasAuthorship W2077886558A5026898912 @default.
- W2077886558 hasAuthorship W2077886558A5042099213 @default.
- W2077886558 hasAuthorship W2077886558A5051005701 @default.
- W2077886558 hasAuthorship W2077886558A5073216396 @default.
- W2077886558 hasAuthorship W2077886558A5074310982 @default.
- W2077886558 hasAuthorship W2077886558A5089606475 @default.
- W2077886558 hasBestOaLocation W20778865582 @default.
- W2077886558 hasConcept C104317684 @default.
- W2077886558 hasConcept C121608353 @default.
- W2077886558 hasConcept C126322002 @default.
- W2077886558 hasConcept C135763542 @default.
- W2077886558 hasConcept C143998085 @default.
- W2077886558 hasConcept C146304588 @default.
- W2077886558 hasConcept C153911025 @default.
- W2077886558 hasConcept C156957248 @default.
- W2077886558 hasConcept C180754005 @default.
- W2077886558 hasConcept C184235292 @default.
- W2077886558 hasConcept C502942594 @default.
- W2077886558 hasConcept C526805850 @default.
- W2077886558 hasConcept C54355233 @default.
- W2077886558 hasConcept C555283112 @default.
- W2077886558 hasConcept C71924100 @default.
- W2077886558 hasConcept C86803240 @default.
- W2077886558 hasConceptScore W2077886558C104317684 @default.
- W2077886558 hasConceptScore W2077886558C121608353 @default.
- W2077886558 hasConceptScore W2077886558C126322002 @default.
- W2077886558 hasConceptScore W2077886558C135763542 @default.
- W2077886558 hasConceptScore W2077886558C143998085 @default.
- W2077886558 hasConceptScore W2077886558C146304588 @default.
- W2077886558 hasConceptScore W2077886558C153911025 @default.
- W2077886558 hasConceptScore W2077886558C156957248 @default.
- W2077886558 hasConceptScore W2077886558C180754005 @default.
- W2077886558 hasConceptScore W2077886558C184235292 @default.