Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077886674> ?p ?o ?g. }
- W2077886674 endingPage "78" @default.
- W2077886674 startingPage "72" @default.
- W2077886674 abstract "Neurons within the periaqueductal gray (PAG) have been implicated in the central regulation of pain signals by affecting the descending inhibitory pathway. Here we report on the functional role of presynaptic kainate receptors within the PAG. Using a conventional whole-cell patch clamp technique, we recorded GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) from mechanically isolated rat PAG neurons in the presence of 300 nM tetrodotoxin and 20 µM dl-2-amino-5-phosphonovaleric acid under voltage-clamp conditions. Kainic acid at a 10 µM concentration significantly increased the frequency of GABAergic mIPSCs without affecting their amplitude, suggesting that kainic acid acts presynaptically to enhance spontaneous GABA release. The kainic acid-induced increase in mIPSC frequency was completely blocked by CNQX, a selective AMPA/kainate receptor antagonist. While neither AMPA nor NMDA affected GABAergic mIPSC frequency, ATPA, a selective agonist of GluR5-containing kainate receptors, increased GABAergic mIPSC frequency in a concentration-dependent manner. The kainic acid-induced increase in mIPSC frequency was completely suppressed either in the presence of 100 µM Cd2+, a general voltage-dependent Ca2+ channel (VDCC) blocker, or in the Na+-free external solution. These results suggest that presynaptic kainate receptors have a low permeability to Ca2+, and that their activation elicits a presynaptic depolarization large enough to activate presynaptic VDCCs. Presynaptic kainate receptors on GABAergic nerve terminals appear to modulate GABAergic transmission, and in doing so may play an important role in the regulation of PAG neuron excitability." @default.
- W2077886674 created "2016-06-24" @default.
- W2077886674 creator A5000063055 @default.
- W2077886674 creator A5005792985 @default.
- W2077886674 creator A5007259468 @default.
- W2077886674 creator A5015524568 @default.
- W2077886674 creator A5019074997 @default.
- W2077886674 creator A5034140606 @default.
- W2077886674 creator A5038629669 @default.
- W2077886674 creator A5048930385 @default.
- W2077886674 creator A5050880653 @default.
- W2077886674 creator A5089857879 @default.
- W2077886674 date "2010-06-01" @default.
- W2077886674 modified "2023-09-25" @default.
- W2077886674 title "Presynaptic kainate receptors increase GABAergic neurotransmission in rat periaqueductal gray neurons" @default.
- W2077886674 cites W1533710876 @default.
- W2077886674 cites W1571689838 @default.
- W2077886674 cites W1620537156 @default.
- W2077886674 cites W1846948211 @default.
- W2077886674 cites W1962526731 @default.
- W2077886674 cites W1986928560 @default.
- W2077886674 cites W1993190350 @default.
- W2077886674 cites W1993292953 @default.
- W2077886674 cites W1993754349 @default.
- W2077886674 cites W1994274358 @default.
- W2077886674 cites W1995606357 @default.
- W2077886674 cites W1995925139 @default.
- W2077886674 cites W1996449721 @default.
- W2077886674 cites W1997848786 @default.
- W2077886674 cites W1998242737 @default.
- W2077886674 cites W2000549249 @default.
- W2077886674 cites W2005903678 @default.
- W2077886674 cites W2009587030 @default.
- W2077886674 cites W2015913538 @default.
- W2077886674 cites W2020098765 @default.
- W2077886674 cites W2037043198 @default.
- W2077886674 cites W2039598635 @default.
- W2077886674 cites W2043873927 @default.
- W2077886674 cites W2046046616 @default.
- W2077886674 cites W2046094549 @default.
- W2077886674 cites W2046599683 @default.
- W2077886674 cites W2048375139 @default.
- W2077886674 cites W2049116056 @default.
- W2077886674 cites W2054183692 @default.
- W2077886674 cites W2062700118 @default.
- W2077886674 cites W2070036878 @default.
- W2077886674 cites W2070143646 @default.
- W2077886674 cites W2073577145 @default.
- W2077886674 cites W2085402579 @default.
- W2077886674 cites W2090730837 @default.
- W2077886674 cites W2092767025 @default.
- W2077886674 cites W2094380375 @default.
- W2077886674 cites W2109826996 @default.
- W2077886674 cites W2118507406 @default.
- W2077886674 cites W2129777420 @default.
- W2077886674 cites W2131695915 @default.
- W2077886674 cites W2132492832 @default.
- W2077886674 cites W2143563675 @default.
- W2077886674 cites W2158389474 @default.
- W2077886674 cites W2162272858 @default.
- W2077886674 cites W2341404010 @default.
- W2077886674 doi "https://doi.org/10.1016/j.ejphar.2010.03.004" @default.
- W2077886674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20303934" @default.
- W2077886674 hasPublicationYear "2010" @default.
- W2077886674 type Work @default.
- W2077886674 sameAs 2077886674 @default.
- W2077886674 citedByCount "6" @default.
- W2077886674 countsByYear W20778866742012 @default.
- W2077886674 countsByYear W20778866742015 @default.
- W2077886674 countsByYear W20778866742017 @default.
- W2077886674 countsByYear W20778866742021 @default.
- W2077886674 crossrefType "journal-article" @default.
- W2077886674 hasAuthorship W2077886674A5000063055 @default.
- W2077886674 hasAuthorship W2077886674A5005792985 @default.
- W2077886674 hasAuthorship W2077886674A5007259468 @default.
- W2077886674 hasAuthorship W2077886674A5015524568 @default.
- W2077886674 hasAuthorship W2077886674A5019074997 @default.
- W2077886674 hasAuthorship W2077886674A5034140606 @default.
- W2077886674 hasAuthorship W2077886674A5038629669 @default.
- W2077886674 hasAuthorship W2077886674A5048930385 @default.
- W2077886674 hasAuthorship W2077886674A5050880653 @default.
- W2077886674 hasAuthorship W2077886674A5089857879 @default.
- W2077886674 hasConcept C112592302 @default.
- W2077886674 hasConcept C12554922 @default.
- W2077886674 hasConcept C160268369 @default.
- W2077886674 hasConcept C168258287 @default.
- W2077886674 hasConcept C169760540 @default.
- W2077886674 hasConcept C170493617 @default.
- W2077886674 hasConcept C17077164 @default.
- W2077886674 hasConcept C185592680 @default.
- W2077886674 hasConcept C189184402 @default.
- W2077886674 hasConcept C200170125 @default.
- W2077886674 hasConcept C2776108384 @default.
- W2077886674 hasConcept C2779177108 @default.
- W2077886674 hasConcept C2779803574 @default.
- W2077886674 hasConcept C55493867 @default.
- W2077886674 hasConcept C61174792 @default.
- W2077886674 hasConcept C86803240 @default.