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- W2077887022 abstract "The X-ray structure of a GCN4 DNA complex (1) shows, that specific DNA binding of the GCN4 basic region Is mediated by a complicated network of base pair and DNA backbone contacts. According to the X-ray structure, alanlne -14 of the basic region of GCN4 (we define the first leuclne of the leucine zipper as +1) makes a hydrophoblc contact to the methyl group of the thymlne next to the center of the GCN4 binding site 5’ ATGACTCAT 3’. We tested the DNA binding properties of the nineteen derivatives of GCN4, which carry all possible amino adds In position -14 of the basic region. Substitution of alanlne -14 of GCN4 by either asparagine or cysteine changes the DNA binding specificity. Serine In this position broadens the specificity for position 1 of the target, whereas other amino acids either retain or decrease GCN4 specificity." @default.
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- W2077887022 date "1993-01-01" @default.
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- W2077887022 title "The DNA binding specificity of the basic region of the yeast transcriptional activator GCN4 can be changed by substitution of a single amino acid" @default.
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- W2077887022 doi "https://doi.org/10.1093/nar/21.9.2081" @default.
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