Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077887593> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2077887593 endingPage "904" @default.
- W2077887593 startingPage "898" @default.
- W2077887593 abstract "Diagnosis of haemophilia A is usually made by the measurement of factor VIII (FVIII) activity that allows categorization of the disease severity. However, tests that assess global haemostasis may better reflect clinical features and give additional clinically relevant information. The aim of this study was to develop a new quantitative activated partial thromboplastin time (aPTT) waveform analysis and compare it with FVIII activities to find out whether waveform parameters are superior determinants of clinical phenotype. A total of 81 haemophilia A patients divided into two groups (37 severe, 44 non-severe) were included in the study. The control group comprised 101 healthy male volunteers. Quantitative aPTT waveform analysis was performed with Actin FS on BCS (Siemens Healthcare Diagnostics, Marburg, Germany) using three parameters (DELTA, RATIO-1, RATIO-2) obtained from a single aPTT measurement with two evaluation modes. FVIII activities were measured by one-stage clotting and two-stage chromogenic assay. Statistically significant difference (P < 0.001) between control group and all haemophilia A patients, as well as between severe and non-severe haemophilia A patients was obtained for all quantitative waveform parameters. Our study revealed parameter DELTA as the best waveform parameter, showing significant correlation with FVIII activities and clinical parameters, and excellent performance for distinguishing between severe and non-severe haemophilia A patients (ROC analysis: sensitivity 97.3%, specificity 93.2%). The results obtained by new quantitative aPTT waveform analysis were superior to those obtained by standard laboratory methods. The simplicity and cost-benefit of the method make this approach a reasonable and promising tool for assessing coagulation in haemophilia A patients." @default.
- W2077887593 created "2016-06-24" @default.
- W2077887593 creator A5004026283 @default.
- W2077887593 creator A5035243916 @default.
- W2077887593 creator A5046437949 @default.
- W2077887593 creator A5082757602 @default.
- W2077887593 date "2014-10-02" @default.
- W2077887593 modified "2023-10-01" @default.
- W2077887593 title "New quantitative <scp>aPTT</scp> waveform analysis and its application in laboratory management of haemophilia A patients" @default.
- W2077887593 cites W125687731 @default.
- W2077887593 cites W1520920065 @default.
- W2077887593 cites W1599667011 @default.
- W2077887593 cites W1964540896 @default.
- W2077887593 cites W1994694158 @default.
- W2077887593 cites W2002743805 @default.
- W2077887593 cites W2003245236 @default.
- W2077887593 cites W2026954003 @default.
- W2077887593 cites W2053115489 @default.
- W2077887593 cites W2138914609 @default.
- W2077887593 cites W2225727988 @default.
- W2077887593 doi "https://doi.org/10.1111/hae.12492" @default.
- W2077887593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25273337" @default.
- W2077887593 hasPublicationYear "2014" @default.
- W2077887593 type Work @default.
- W2077887593 sameAs 2077887593 @default.
- W2077887593 citedByCount "7" @default.
- W2077887593 countsByYear W20778875932017 @default.
- W2077887593 countsByYear W20778875932018 @default.
- W2077887593 countsByYear W20778875932019 @default.
- W2077887593 countsByYear W20778875932020 @default.
- W2077887593 crossrefType "journal-article" @default.
- W2077887593 hasAuthorship W2077887593A5004026283 @default.
- W2077887593 hasAuthorship W2077887593A5035243916 @default.
- W2077887593 hasAuthorship W2077887593A5046437949 @default.
- W2077887593 hasAuthorship W2077887593A5082757602 @default.
- W2077887593 hasBestOaLocation W20778875931 @default.
- W2077887593 hasConcept C126322002 @default.
- W2077887593 hasConcept C141071460 @default.
- W2077887593 hasConcept C197424946 @default.
- W2077887593 hasConcept C2777232031 @default.
- W2077887593 hasConcept C2777664302 @default.
- W2077887593 hasConcept C2778261982 @default.
- W2077887593 hasConcept C2778382381 @default.
- W2077887593 hasConcept C2778385053 @default.
- W2077887593 hasConcept C2778589496 @default.
- W2077887593 hasConcept C2780434524 @default.
- W2077887593 hasConcept C41008148 @default.
- W2077887593 hasConcept C554190296 @default.
- W2077887593 hasConcept C71924100 @default.
- W2077887593 hasConcept C76155785 @default.
- W2077887593 hasConceptScore W2077887593C126322002 @default.
- W2077887593 hasConceptScore W2077887593C141071460 @default.
- W2077887593 hasConceptScore W2077887593C197424946 @default.
- W2077887593 hasConceptScore W2077887593C2777232031 @default.
- W2077887593 hasConceptScore W2077887593C2777664302 @default.
- W2077887593 hasConceptScore W2077887593C2778261982 @default.
- W2077887593 hasConceptScore W2077887593C2778382381 @default.
- W2077887593 hasConceptScore W2077887593C2778385053 @default.
- W2077887593 hasConceptScore W2077887593C2778589496 @default.
- W2077887593 hasConceptScore W2077887593C2780434524 @default.
- W2077887593 hasConceptScore W2077887593C41008148 @default.
- W2077887593 hasConceptScore W2077887593C554190296 @default.
- W2077887593 hasConceptScore W2077887593C71924100 @default.
- W2077887593 hasConceptScore W2077887593C76155785 @default.
- W2077887593 hasIssue "6" @default.
- W2077887593 hasLocation W20778875931 @default.
- W2077887593 hasLocation W20778875932 @default.
- W2077887593 hasOpenAccess W2077887593 @default.
- W2077887593 hasPrimaryLocation W20778875931 @default.
- W2077887593 hasRelatedWork W1591132000 @default.
- W2077887593 hasRelatedWork W2125507918 @default.
- W2077887593 hasRelatedWork W2283167177 @default.
- W2077887593 hasRelatedWork W2330460854 @default.
- W2077887593 hasRelatedWork W2413023519 @default.
- W2077887593 hasRelatedWork W2421123155 @default.
- W2077887593 hasRelatedWork W2951281702 @default.
- W2077887593 hasRelatedWork W3192750797 @default.
- W2077887593 hasRelatedWork W2601332153 @default.
- W2077887593 hasRelatedWork W3148718224 @default.
- W2077887593 hasVolume "20" @default.
- W2077887593 isParatext "false" @default.
- W2077887593 isRetracted "false" @default.
- W2077887593 magId "2077887593" @default.
- W2077887593 workType "article" @default.