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• W2077888878 startingPage "1" @default.
• W2077888878 abstract "Maternal infection and maternal immune activation (MIA) during pregnancy increase risks for psychiatric disorders such as schizophrenia and autism. Many deficits related to psychiatric disorders are observed in adult offspring of MIA animal models, including behavioral abnormalities, morphological defects in various brain regions, and dysregulation of neurotransmitter systems. It has previously been shown that MIA impairs adult neurogenesis in the dentate gyrus of the hippocampus. In this study, we examined whether MIA affects adult neurogenesis in the subventricular zone (SVZ)–olfactory bulb (OB) pathway. Polyinosinic–polycytidylic acid (PolyI:C), a synthetic analog of double-stranded RNA mimicking viral infection, was injected into pregnant mice on gestation day 9.5 to activate immune systems. In the SVZ–OB pathway of adult offspring, different cell types of the neural stem cell lineage responded differently to MIA. Neural stem cells and neuroblasts were decreased. Cell proliferation of transit-amplifying cells was impaired. Consequently, newborn neurons were reduced in the OB. Olfactory deficiency has been suggested as a biomarker for schizophrenia. Here we found that olfactory discrimination was compromised in adult MIA offspring. Taken together, these findings show that MIA leads to defective adult neurogenesis in the SVZ–OB pathway, and the impairment of adult neurogenesis may lead to deficits in olfactory functions." @default.
• W2077888878 created "2016-06-24" @default.
• W2077888878 creator A5037706185 @default.
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• W2077888878 creator A5079129261 @default.
• W2077888878 date "2013-12-01" @default.
• W2077888878 modified "2023-09-25" @default.
• W2077888878 title "Effects of maternal immune activation on adult neurogenesis in the subventricular zone–olfactory bulb pathway and olfactory discrimination" @default.
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• W2077888878 doi "https://doi.org/10.1016/j.schres.2013.09.007" @default.
• W2077888878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24113206" @default.
• W2077888878 hasPublicationYear "2013" @default.
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