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- W2077889788 abstract "The type of experiment is considered in which a whole body dose of ionizing radiation is acutely administered to a test group of animals; after a specified period of time those still surviving are administered a second such dose. This procedure is repeatable on a number of such test groups using a different dose magnitude and intervals of separation for each group. Three exhaustive time intervals can be considered in which first interval deaths can be ascribed primarily to the first dose, those in the second to the additive effects of the second dose with the residual effect of the first dose, and those not dying until the third interval are considered survivors of the two doses. A mathematical model is derived for the analysis of such data that is a logical extension of the rationale used in the probit analysis of acute single dose data. Injury is postulated to be comprised of two additive components, one permanent and one recoverable. The recoverable injury decrements exponentially with time. Death occurs when the total injury exceeds the lethal threshold of an animal. The logarithm of the lethal thresholds of an animal at two different times is assumed to be bivariate normally distributed with a correlation depending upon the absolute magnitude of the difference between the two times. An iterative calculation procedure is presented for obtaining the maximum likelihood estimates of the relevant parameters and the variances and covariances of these estimates from experimental data of type described above." @default.
- W2077889788 created "2016-06-24" @default.
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- W2077889788 date "1959-04-01" @default.
- W2077889788 modified "2023-09-26" @default.
- W2077889788 title "Maximum Likelihood Analysis of Ionizing Radiation Induced Mortality in Whole Body Fractionated Dose Experiments" @default.
- W2077889788 doi "https://doi.org/10.1097/00004032-195904000-00003" @default.
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