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- W2077889827 abstract "Angiogenesis, is essential for tumour growth beyond 1–2 mm in diameter. In malignant tumours such as renal-cell cancer (RCC), high microvessel counts, an indirect measure of angiogenesis, are associated with a poor prognosis. 1 Yoshino S Kato M Odaka K Prognostic significance of microvessel count in low stage renal cell carcinoma. Int J Urol. 1995; 2: 156-160 Crossref PubMed Scopus (98) Google Scholar Vascular endothelial growth factor (VEGF) is a homodimeric cytokine encoded on chromosome 6p21·3. Due to alternative exon splicing, four different forms of VEGF have been identified, of 121, 165, 189, and 206 aminoacids. VEGF is a potent stimulator of angiogenesis both in vitro and in vivo. 2 Takahashi A Sasaki H Kim SJ et al. Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placental growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res. 1994; 54: 4333-4337 Google Scholar , 3 Banks RE Forbes MA Kinsey SE et al. Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology. Br J Cancer. 1998; 77: 956-964 Crossref PubMed Scopus (515) Google Scholar In RCC, overexpression of VEGF is associated with tumour angiogenesis. 3 Banks RE Forbes MA Kinsey SE et al. Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology. Br J Cancer. 1998; 77: 956-964 Crossref PubMed Scopus (515) Google Scholar In patients with cancer a positive correlation between serum VEGF levels and disease progression has been shown. 4 Dirix LY Vermeulen PB Hubens G et al. Serum basic fibroblast growth factor and vascular endothelial growth factor and tumour growth kinetics in advanced colorectal cancer. Ann Oncol. 1996; 7: 843-848 Crossref PubMed Scopus (136) Google Scholar" @default.
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- W2077889827 date "1999-05-01" @default.
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- W2077889827 title "Vascular endothelial growth factor platelet counts, and prognosis in renal cancer" @default.
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