FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077890045> ?p ?o ?g. }

• W2077890045 endingPage "1316" @default.
• W2077890045 startingPage "1310" @default.
• W2077890045 abstract "Although aberrant DNA methylation has been implicated in the pathophysiology of lung cancer, the role of methylation in multidrug resistance (MDR) of lung cancer has remained unclear. To investigate whether certain distinct DNA methylation pattern is associated with acquired MDR of lung adenocarcinoma, methylated-DNA immunoprecipitation-chromatin immunoprecipitation (MeDIP-ChIP) was utilised to compare the genome-wide promoter methylation of the human lung adenocarcinoma MDR A549/cisplatin (A549/DDP) cells with its progenitor A549 cells. The comparison identified 3617 genes with differentially methylated promoter, of which 1581 were hypermethylated and 2036 were hypomethylated. Then, bisulphite sequencing polymerase chain reaction (PCR) (BSP) and quantitative reverse transcription (RT)-PCR (Q-PCR) were used to validate the promoter methylation of five candidate genes and to determine whether the expression of genes was associated with the promoter methylation. BSP confirmed that the promoter methylation incidence of the hypermethylated genes, G protein-coupled receptor 56 isoform 3 (GPR56), metallothionein 1G (MT1G), and RAS association domain family gene 1 (RASSF1), was significantly higher in A549/DDP cells compared with A549 cells (p<0.001, p=0.0099, and p=0.0165), whereas no significant difference was found in that of the other two genes, CCNL2 and BAD (p=0.0594 and p=0.5546). Additionally, Q-PCR showed that the mRNA expression of the three hypermethylated genes was significantly lower in A549/DDP cells compared with A549 cells (all p<0.001). In conclusion, this study reported for the first time that a distinct promoter methylation pattern is associated with MDR of lung adenocarcinoma A549/DDP cells and suggested that GPR56, MT1G, and RASSF1 might be the potential methylation markers associated with acquired MDR of lung adenocarcinoma." @default.
• W2077890045 created "2016-06-24" @default.
• W2077890045 creator A5000803243 @default.
• W2077890045 creator A5007222967 @default.
• W2077890045 creator A5016633230 @default.
• W2077890045 creator A5019130868 @default.
• W2077890045 creator A5021852513 @default.
• W2077890045 creator A5044954885 @default.
• W2077890045 creator A5054451012 @default.
• W2077890045 creator A5071405178 @default.
• W2077890045 creator A5085035359 @default.
• W2077890045 date "2013-01-01" @default.
• W2077890045 modified "2023-10-10" @default.
• W2077890045 title "Promoter Methylation Profiles between Human Lung Adenocarcinoma Multidrug Resistant A549/Cisplatin (A549/DDP) Cells and Its Progenitor A549 Cells" @default.
• W2077890045 cites W1512927198 @default.
• W2077890045 cites W1969116114 @default.
• W2077890045 cites W1984789674 @default.
• W2077890045 cites W2003256314 @default.
• W2077890045 cites W2013485244 @default.
• W2077890045 cites W2074180520 @default.
• W2077890045 cites W2085947779 @default.
• W2077890045 cites W2106356851 @default.
• W2077890045 cites W2107277218 @default.
• W2077890045 cites W2133452708 @default.
• W2077890045 cites W2140757273 @default.
• W2077890045 cites W2166783717 @default.
• W2077890045 doi "https://doi.org/10.1248/bpb.b13-00153" @default.
• W2077890045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23902976" @default.
• W2077890045 hasPublicationYear "2013" @default.
• W2077890045 type Work @default.
• W2077890045 sameAs 2077890045 @default.
• W2077890045 citedByCount "27" @default.
• W2077890045 countsByYear W20778900452014 @default.
• W2077890045 countsByYear W20778900452015 @default.
• W2077890045 countsByYear W20778900452016 @default.
• W2077890045 countsByYear W20778900452017 @default.
• W2077890045 countsByYear W20778900452018 @default.
• W2077890045 countsByYear W20778900452019 @default.
• W2077890045 countsByYear W20778900452020 @default.
• W2077890045 countsByYear W20778900452021 @default.
• W2077890045 countsByYear W20778900452022 @default.
• W2077890045 countsByYear W20778900452023 @default.
• W2077890045 crossrefType "journal-article" @default.
• W2077890045 hasAuthorship W2077890045A5000803243 @default.
• W2077890045 hasAuthorship W2077890045A5007222967 @default.
• W2077890045 hasAuthorship W2077890045A5016633230 @default.
• W2077890045 hasAuthorship W2077890045A5019130868 @default.
• W2077890045 hasAuthorship W2077890045A5021852513 @default.
• W2077890045 hasAuthorship W2077890045A5044954885 @default.
• W2077890045 hasAuthorship W2077890045A5054451012 @default.
• W2077890045 hasAuthorship W2077890045A5071405178 @default.
• W2077890045 hasAuthorship W2077890045A5085035359 @default.
• W2077890045 hasBestOaLocation W20778900451 @default.
• W2077890045 hasConcept C101762097 @default.
• W2077890045 hasConcept C104317684 @default.
• W2077890045 hasConcept C121608353 @default.
• W2077890045 hasConcept C134320426 @default.
• W2077890045 hasConcept C150194340 @default.
• W2077890045 hasConcept C153911025 @default.
• W2077890045 hasConcept C189235521 @default.
• W2077890045 hasConcept C190727270 @default.
• W2077890045 hasConcept C2781182431 @default.
• W2077890045 hasConcept C33288867 @default.
• W2077890045 hasConcept C502942594 @default.
• W2077890045 hasConcept C54355233 @default.
• W2077890045 hasConcept C81729549 @default.
• W2077890045 hasConcept C81885089 @default.
• W2077890045 hasConcept C86803240 @default.
• W2077890045 hasConceptScore W2077890045C101762097 @default.
• W2077890045 hasConceptScore W2077890045C104317684 @default.
• W2077890045 hasConceptScore W2077890045C121608353 @default.
• W2077890045 hasConceptScore W2077890045C134320426 @default.
• W2077890045 hasConceptScore W2077890045C150194340 @default.
• W2077890045 hasConceptScore W2077890045C153911025 @default.
• W2077890045 hasConceptScore W2077890045C189235521 @default.
• W2077890045 hasConceptScore W2077890045C190727270 @default.
• W2077890045 hasConceptScore W2077890045C2781182431 @default.
• W2077890045 hasConceptScore W2077890045C33288867 @default.
• W2077890045 hasConceptScore W2077890045C502942594 @default.
• W2077890045 hasConceptScore W2077890045C54355233 @default.
• W2077890045 hasConceptScore W2077890045C81729549 @default.
• W2077890045 hasConceptScore W2077890045C81885089 @default.
• W2077890045 hasConceptScore W2077890045C86803240 @default.
• W2077890045 hasIssue "8" @default.
• W2077890045 hasLocation W20778900451 @default.
• W2077890045 hasLocation W20778900452 @default.
• W2077890045 hasOpenAccess W2077890045 @default.
• W2077890045 hasPrimaryLocation W20778900451 @default.
• W2077890045 hasRelatedWork W1983904019 @default.
• W2077890045 hasRelatedWork W1991992597 @default.
• W2077890045 hasRelatedWork W2008124071 @default.
• W2077890045 hasRelatedWork W2033244804 @default.
• W2077890045 hasRelatedWork W2063135470 @default.
• W2077890045 hasRelatedWork W2084826818 @default.
• W2077890045 hasRelatedWork W2127500890 @default.
• W2077890045 hasRelatedWork W2595064405 @default.
• W2077890045 hasRelatedWork W2911544435 @default.
• W2077890045 hasRelatedWork W3031751016 @default.

• next