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• W2077890055 abstract "Using near-infrared time-resolved spectroscopy (TRS), we measured the human head in transmittance mode to obtain theoptical properties, tissue oxygenation, and hemodynamics of deep brain tissues in 50 healthy adult volunteers. The rightear canal was irradiated with 3-wavelengths of pulsed light (760, 795, and 835nm), and the photons passing through thehuman head were collected at the left ear canal. Optical signals with sufficient intensity could be obtained from 46 of the50 volunteers. By analyzing the temporal profiles based on the photon diffusion theory, we successfully obtainedabsorption coefficients for each wavelength. The levels of oxygenated hemoglobin (HbO 2 ), deoxygenated hemoglobin(Hb), total hemoglobin (tHb), and tissue oxygen saturation (SO 2 ) were then determined by referring to the hemoglobinspectroscopic data. Compared with the SO 2 values for the forehead measurements in reflectance mode, the SO 2 values of the transmittance measurements of the human head were approximately 10% lower, and tHb values of the transmittance measurements were always lower than those of the forehead reflectance measurements. Moreover, the level ofhemoglobin and the SO 2 were strongly correlated between the human head measurements in transmittance mode and the forehead measurements in the reflectance mode, respectively. These results demonstrated a potential application of this TRS system in examining deep brain tissues of humans." @default.
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• W2077890055 date "2014-03-05" @default.
• W2077890055 modified "2023-09-26" @default.
• W2077890055 title "Hemodynamic measurements in deep brain tissues of humans by near-infrared time-resolved spectroscopy" @default.
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• W2077890055 doi "https://doi.org/10.1117/12.2038689" @default.
• W2077890055 hasPublicationYear "2014" @default.
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