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• W2077890614 abstract "One of the hallmarks of cancer is genomic instability controlled by cell cycle checkpoints. The G1 and G2 checkpoints allow DNA damage responses, whereas the mitotic checkpoint enables correct seggregation of the sister chromosomes to prevent aneuploidy. Cancer cells often lack a functional G1 arrest and rely on G2 arrest for DNA damage responses. WEE1 kinase is an important regulator of the G2 checkpoint and is overexpressed in various cancer types. Inhibition of WEE1 is a promising strategy in cancer therapy in combination with DNA-damaging agents, especially when cancer cells harbor p53 mutations, as it causes mitotic catastrophy when DNA is not repaired during G2 arrest. Cancer cell response to WEE1 inhibition monotherapy has also been demonstrated in various types of cancer, including p53 wild-type cancers. We postulate that chromosomal instability can explain tumor response to WEE1 monotherapy. Therefore, chromosomal instability may need to be taken into account when determining the most effective strategy for the use of WEE1 inhibitors in cancer therapy." @default.
• W2077890614 created "2016-06-24" @default.
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• W2077890614 date "2013-12-01" @default.
• W2077890614 modified "2023-10-18" @default.
• W2077890614 title "WEE1 inhibition and genomic instability in cancer" @default.
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• W2077890614 cites W1965560988 @default.
• W2077890614 cites W1966669440 @default.
• W2077890614 cites W1967880683 @default.
• W2077890614 cites W1972518056 @default.
• W2077890614 cites W1973916918 @default.
• W2077890614 cites W1981667064 @default.
• W2077890614 cites W1987084496 @default.
• W2077890614 cites W1991403537 @default.
• W2077890614 cites W1991494214 @default.
• W2077890614 cites W1999403469 @default.
• W2077890614 cites W1999727181 @default.
• W2077890614 cites W2002246796 @default.
• W2077890614 cites W2002803432 @default.
• W2077890614 cites W2003381961 @default.
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• W2077890614 cites W2007305884 @default.
• W2077890614 cites W2009024120 @default.
• W2077890614 cites W2011517124 @default.
• W2077890614 cites W2020495169 @default.
• W2077890614 cites W2021278812 @default.
• W2077890614 cites W2022527641 @default.
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• W2077890614 cites W2142325694 @default.
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• W2077890614 doi "https://doi.org/10.1016/j.bbcan.2013.05.002" @default.
• W2077890614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23727417" @default.
• W2077890614 hasPublicationYear "2013" @default.
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