Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077891139> ?p ?o ?g. }
- W2077891139 endingPage "396" @default.
- W2077891139 startingPage "383" @default.
- W2077891139 abstract "The combination of isotretinoin (13-cis-retinoic acid) with antiestrogens seems to be a promising strategy for cancer chemotherapy. The aim of the study was to evaluate the effects of isotretinoin alone or in combination with 4-hydroxytamoxifen (OHTAM) and with its prodrug tamoxifen (TAM), on the functions of rat liver mitochondria, i.e., mitochondrial permeability transition (MPT), bioenergetic functions and adenine nucleotide translocase (ANT). Isotretinoin (5 nmol/mg protein) induced the Ca2+-dependent MPT pore opening in mitochondria energized with succinate, which was prevented by OHTAM, cyclosporine A, TAM and ANT ligands. When mitochondria were energized with glutamate/malate and in the absence of added Ca2+ isotretinoin decreased the state 3 respiration, the ATP levels, the active ANT content and increased the lag phase of the phosphorylation cycle, demonstrating that isotretinoin decreased the mitochondrial phosphorylation efficiency. These changes of isotretinoin in bioenergetic parameters were not significant in the presence of succinate. The effects of isotretinoin at 5 nmol/mg protein on the Ca2+-dependent MPT and phosphorylative efficacy may be related with interactions with the ANT. Above 10 nmol/mg protein isotretinoin strongly diminished the active ANT content, decreased the Δψ, inhibited the complex I and induced proton leak through the Fo fraction of complex V. The combination of OHTAM with isotretinoin only induced significant changes in the energy production systems at concentrations ≥5 nmol isotretinoin/mg protein. Therefore, our results suggest that isotretinoin-associated liver toxicity is possibly related with mitochondrial dysfunctions and that the combination with OHTAM may contribute to decrease its toxicity." @default.
- W2077891139 created "2016-06-24" @default.
- W2077891139 creator A5020368197 @default.
- W2077891139 creator A5026086117 @default.
- W2077891139 creator A5034558584 @default.
- W2077891139 creator A5041554767 @default.
- W2077891139 creator A5050399538 @default.
- W2077891139 creator A5070226332 @default.
- W2077891139 date "2013-06-19" @default.
- W2077891139 modified "2023-10-16" @default.
- W2077891139 title "The antiestrogen 4-hydroxytamoxifen protects against isotretinoin-induced permeability transition and bioenergetic dysfunction of liver mitochondria: comparison with tamoxifen" @default.
- W2077891139 cites W1492823505 @default.
- W2077891139 cites W1506043065 @default.
- W2077891139 cites W1544901029 @default.
- W2077891139 cites W1564026327 @default.
- W2077891139 cites W1586425912 @default.
- W2077891139 cites W1927684145 @default.
- W2077891139 cites W1966355764 @default.
- W2077891139 cites W1968501645 @default.
- W2077891139 cites W1970099316 @default.
- W2077891139 cites W1979032970 @default.
- W2077891139 cites W1981108341 @default.
- W2077891139 cites W1981125500 @default.
- W2077891139 cites W1982009338 @default.
- W2077891139 cites W1984780346 @default.
- W2077891139 cites W1986228979 @default.
- W2077891139 cites W1989139878 @default.
- W2077891139 cites W1992546410 @default.
- W2077891139 cites W1999761537 @default.
- W2077891139 cites W2007515181 @default.
- W2077891139 cites W2008422990 @default.
- W2077891139 cites W2009290673 @default.
- W2077891139 cites W2017958217 @default.
- W2077891139 cites W2023420264 @default.
- W2077891139 cites W2026140728 @default.
- W2077891139 cites W2033737465 @default.
- W2077891139 cites W2035189174 @default.
- W2077891139 cites W2037677030 @default.
- W2077891139 cites W2037813255 @default.
- W2077891139 cites W2038077225 @default.
- W2077891139 cites W2041089371 @default.
- W2077891139 cites W2052406949 @default.
- W2077891139 cites W2053999202 @default.
- W2077891139 cites W2057767639 @default.
- W2077891139 cites W2058590063 @default.
- W2077891139 cites W2061934526 @default.
- W2077891139 cites W2062636899 @default.
- W2077891139 cites W2063284227 @default.
- W2077891139 cites W2063553111 @default.
- W2077891139 cites W2067831243 @default.
- W2077891139 cites W2074797884 @default.
- W2077891139 cites W2076887183 @default.
- W2077891139 cites W2078142880 @default.
- W2077891139 cites W2078473838 @default.
- W2077891139 cites W2080562615 @default.
- W2077891139 cites W2080683349 @default.
- W2077891139 cites W2081913985 @default.
- W2077891139 cites W2082604451 @default.
- W2077891139 cites W2085817426 @default.
- W2077891139 cites W2086034778 @default.
- W2077891139 cites W2091300408 @default.
- W2077891139 cites W2098403002 @default.
- W2077891139 cites W2110144897 @default.
- W2077891139 cites W2114429287 @default.
- W2077891139 cites W2128365100 @default.
- W2077891139 cites W2144277227 @default.
- W2077891139 cites W2154402901 @default.
- W2077891139 cites W2169028428 @default.
- W2077891139 cites W2170517394 @default.
- W2077891139 doi "https://doi.org/10.1007/s10863-013-9517-9" @default.
- W2077891139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23779226" @default.
- W2077891139 hasPublicationYear "2013" @default.
- W2077891139 type Work @default.
- W2077891139 sameAs 2077891139 @default.
- W2077891139 citedByCount "4" @default.
- W2077891139 countsByYear W20778911392014 @default.
- W2077891139 countsByYear W20778911392015 @default.
- W2077891139 countsByYear W20778911392023 @default.
- W2077891139 crossrefType "journal-article" @default.
- W2077891139 hasAuthorship W2077891139A5020368197 @default.
- W2077891139 hasAuthorship W2077891139A5026086117 @default.
- W2077891139 hasAuthorship W2077891139A5034558584 @default.
- W2077891139 hasAuthorship W2077891139A5041554767 @default.
- W2077891139 hasAuthorship W2077891139A5050399538 @default.
- W2077891139 hasAuthorship W2077891139A5070226332 @default.
- W2077891139 hasBestOaLocation W20778911392 @default.
- W2077891139 hasConcept C100206155 @default.
- W2077891139 hasConcept C11960822 @default.
- W2077891139 hasConcept C126322002 @default.
- W2077891139 hasConcept C134018914 @default.
- W2077891139 hasConcept C185592680 @default.
- W2077891139 hasConcept C2776285725 @default.
- W2077891139 hasConcept C2777071529 @default.
- W2077891139 hasConcept C2777673923 @default.
- W2077891139 hasConcept C28859421 @default.
- W2077891139 hasConcept C54355233 @default.
- W2077891139 hasConcept C55493867 @default.
- W2077891139 hasConcept C71924100 @default.