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- W20778914 abstract "Nicotinic acetylcholine receptors (nAChRs) are a critical component of the brain’s cholinergic neurotransmission system that modulates important physiological processes and whose dysfunction has been observed in patients with neurodegenerative diseases and mental illness. nAChRs are a heterogeneous family of receptor subtypes consisting of pentameric combinations of α and β subunits, and are widely expressed throughout the central and peripheral nervous system. nAChR subtypesnAChR subtypes share a common basic structure but their biophysical and pharmacological properties depend on their subunit compositionSubunit composition , which is therefore central to understanding receptor function in the nervous system and discovering new subtype-selective drugs. We briefly review some recent findings concerning the structure and function of nAChRs, particularly the native subtypes." @default.
- W20778914 created "2016-06-24" @default.
- W20778914 creator A5003491531 @default.
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- W20778914 date "2015-01-01" @default.
- W20778914 modified "2023-10-10" @default.
- W20778914 title "Structure of Neuronal Nicotinic Receptors" @default.
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- W20778914 doi "https://doi.org/10.1007/978-3-319-13665-3_1" @default.
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