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• W2077891508 abstract "Cholesterol is involved in endocytosis, exocytosis, and the assembly of sphingolipid/cholesterol-enriched domains, as has been demonstrated in both model membranes and living cells. In this work, we explored the influence of different cholesterol levels (5–40 mol %) on the morphology and nanomechanical stability of phase-segregated lipid bilayers consisting of dioleoylphosphatidylcholine/sphingomyelin/cholesterol (DOPC/SM/Chol) by means of atomic force microscopy (AFM) imaging and force mapping. Breakthrough forces were consistently higher in the SM/Chol-enriched liquid-ordered domains (Lo) than in the DOPC-enriched fluid-disordered phase (Ld) at a series of loading rates. We also report the activation energies (ΔEa) for the formation of an AFM-tip-induced fracture, calculated by a model for the rupture of molecular thin films. The obtained ΔEa values agree remarkably well with reported values for fusion-related processes using other techniques. Furthermore, we observed that within the Chol range studied, the lateral organization of bilayers can be categorized into three distinct groups. The results are rationalized by fracture nanomechanics of a ternary phospholipid/sphingolipid/cholesterol mixture using correlated AFM-based imaging and force mapping, which demonstrates the influence of a wide range of cholesterol content on the morphology and nanomechanical stability of model bilayers. This provides fundamental insights into the role of cholesterol in the formation and stability of sphingolipid/cholesterol-enriched domains, as well as in membrane fusion." @default.
• W2077891508 created "2016-06-24" @default.
• W2077891508 creator A5009559290 @default.
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• W2077891508 creator A5033380723 @default.
• W2077891508 creator A5075087804 @default.
• W2077891508 creator A5086630277 @default.
• W2077891508 date "2010-07-01" @default.
• W2077891508 modified "2023-10-07" @default.
• W2077891508 title "Cholesterol-Dependent Nanomechanical Stability of Phase-Segregated Multicomponent Lipid Bilayers" @default.
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• W2077891508 doi "https://doi.org/10.1016/j.bpj.2010.04.044" @default.
• W2077891508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2905127" @default.
• W2077891508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20643069" @default.
• W2077891508 hasPublicationYear "2010" @default.
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