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• W2077894928 endingPage "578" @default.
• W2077894928 startingPage "573" @default.
• W2077894928 abstract "Benzodiazepines have been useful tools for investigating mechanisms underlying learning and memory. The present set of experiments investigates the role of hippocampal GABA(A)/benzodiazepine receptors in memory consolidation using Pavlovian fear conditioning. Rats were prepared with cannulae aimed at the dorsal hippocampus and trained with a series of white noise-shock pairings. In the first experiment, animals received intrahippocampal infusion of midazolam or vehicle immediately or 3 h after training. Then, 24 h later, freezing to the training context and the white noise were measured independently. Results show infusion of midazolam immediately, but not 3 h, after training selectively attenuates contextual fear conditioning. In the second experiment, animals received intrahippocampal infusions of an antisense oligodeoxynucleotide (ODN) targeting the alpha5 subunit of the GABA(A) receptor or a missense control for several days prior to training and testing. Immediately after training, animals received an infusion of either midazolam or vehicle. Western blots conducted after testing showed a significant decrease in alpha5-containing GABA(A) receptor protein. This reduction did not alter the effectiveness of midazolam immediately after training at impairing context fear memory. Therefore, alpha5-containing GABA(A) receptors may not contribute to the effects of midazolam on context fear conditioning when given immediately post-training." @default.
• W2077894928 created "2016-06-24" @default.
• W2077894928 creator A5050992492 @default.
• W2077894928 creator A5075128887 @default.
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• W2077894928 date "2005-11-01" @default.
• W2077894928 modified "2023-09-30" @default.
• W2077894928 title "Effects of post-training hippocampal injections of midazolam on fear conditioning" @default.
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• W2077894928 doi "https://doi.org/10.1101/lm.51305" @default.
• W2077894928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1356174" @default.
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