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• W2077895426 abstract "<h3>ABSTRACT</h3> <h3>Objective:</h3> To assess the utility of orexin receptor antagonism as a novel approach to treating insomnia. <h3>Methods:</h3> We evaluated suvorexant, an orexin receptor antagonist, for treating patients with primary insomnia in a randomized, double-blind, placebo-controlled, 2-period (4 weeks per period) crossover polysomnography study. Patients received suvorexant (10 mg [n = 62], 20 mg [n = 61], 40 mg [n = 59], or 80 mg [n = 61]) in one period and placebo (n = 249) in the other. Polysomnography was performed on night 1 and at the end of week 4 of each period. The coprimary efficacy end points were sleep efficiency on night 1 and end of week 4. Secondary end points were wake after sleep onset and latency to persistent sleep. <h3>Results:</h3> Suvorexant showed significant (<i>p</i> values <0.01) dose-related improvements vs placebo on the coprimary end points of sleep efficiency at night 1 and end of week 4. Dose-related effects were also observed for sleep induction (latency to persistent sleep) and maintenance (wake after sleep onset). Suvorexant was generally well tolerated. <h3>Conclusions:</h3> The data suggest that orexin receptor antagonism offers a novel approach to treating insomnia. <h3>Classification of evidence:</h3> This study provides Class I evidence that suvorexant improves sleep efficiency over 4 weeks in nonelderly adult patients with primary insomnia." @default.
• W2077895426 created "2016-06-24" @default.
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• W2077895426 date "2012-11-28" @default.
• W2077895426 modified "2023-10-03" @default.
• W2077895426 title "Orexin receptor antagonism for treatment of insomnia: A randomized clinical trial of suvorexant" @default.
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• W2077895426 doi "https://doi.org/10.1212/wnl.0b013e31827688ee" @default.
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