FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077897146> ?p ?o ?g. }

• W2077897146 endingPage "237" @default.
• W2077897146 startingPage "232" @default.
• W2077897146 abstract "The aim of the present study was to evaluate the role of K+ channels in the vasorelaxant effect of the phosphodiesterase 5 inhibitor, sildenafil, in isolated horse penile resistance arteries mounted in microvascular myographs. In phenylephrine-precontracted arteries, sildenafil elicited potent relaxations which were markedly reduced by raising extracellular K+, by the non-selective blocker of Ca2+-activated K+ channels (KCa), tetraethylammonium and by the blocker of large- and intermediate-conductance KCa channels, charybdotoxin. Sildenafil relaxant responses were also reduced by the selective inhibitor of large conductance KCa (BK(Ca)) channels iberiotoxin, but not by the blocker of small conductance KCa channels apamin. The inhibitor of the cGMP-dependent protein kinase (PKG), Rp-8-Br-PET-cGMPS, reduced the relaxations elicited by sildenafil but combined treatment with iberiotoxin and Rp-8-Br-PET-cGMPS did not further inhibit these relaxations, compared to the effect of either blocker alone. Iberiotoxin also shifted to the right the relaxations elicited by both the NO donor, S-nitrosoacetyl-D,L-penicillamine (SNAP) and the adenylate cyclase activator forskolin; treatment with both iberiotoxin and Rp-8-Br-PET-cGMPS did cause an additional inhibition. The present results demonstrate that the relaxant effect of sildenafil and NO in penile resistance arteries is due in part to activation of BK(Ca) channels through a PKG-dependent mechanism." @default.
• W2077897146 created "2016-06-24" @default.
• W2077897146 creator A5016224747 @default.
• W2077897146 creator A5040864474 @default.
• W2077897146 creator A5045447593 @default.
• W2077897146 creator A5057839161 @default.
• W2077897146 creator A5069600944 @default.
• W2077897146 creator A5076727242 @default.
• W2077897146 creator A5088788784 @default.
• W2077897146 date "2006-02-01" @default.
• W2077897146 modified "2023-10-18" @default.
• W2077897146 title "Ca2+-activated K+ (KCa) channels are involved in the relaxations elicited by sildenafil in penile resistance arteries" @default.
• W2077897146 cites W110557356 @default.
• W2077897146 cites W1753089048 @default.
• W2077897146 cites W1976129213 @default.
• W2077897146 cites W1987152234 @default.
• W2077897146 cites W1993492621 @default.
• W2077897146 cites W1994989484 @default.
• W2077897146 cites W2005196967 @default.
• W2077897146 cites W2008749541 @default.
• W2077897146 cites W2018413966 @default.
• W2077897146 cites W2021974542 @default.
• W2077897146 cites W2030896642 @default.
• W2077897146 cites W2038185189 @default.
• W2077897146 cites W2044869734 @default.
• W2077897146 cites W2049472065 @default.
• W2077897146 cites W2065277421 @default.
• W2077897146 cites W2069624169 @default.
• W2077897146 cites W2087023174 @default.
• W2077897146 cites W2102426153 @default.
• W2077897146 cites W2130400938 @default.
• W2077897146 cites W2134184057 @default.
• W2077897146 cites W2136176802 @default.
• W2077897146 cites W2139469890 @default.
• W2077897146 cites W2149442247 @default.
• W2077897146 cites W2152187474 @default.
• W2077897146 cites W2164189667 @default.
• W2077897146 cites W2256724151 @default.
• W2077897146 cites W22857079 @default.
• W2077897146 cites W2321760725 @default.
• W2077897146 doi "https://doi.org/10.1016/j.ejphar.2005.12.033" @default.
• W2077897146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16443214" @default.
• W2077897146 hasPublicationYear "2006" @default.
• W2077897146 type Work @default.
• W2077897146 sameAs 2077897146 @default.
• W2077897146 citedByCount "25" @default.
• W2077897146 countsByYear W20778971462013 @default.
• W2077897146 countsByYear W20778971462015 @default.
• W2077897146 countsByYear W20778971462016 @default.
• W2077897146 countsByYear W20778971462017 @default.
• W2077897146 countsByYear W20778971462019 @default.
• W2077897146 countsByYear W20778971462020 @default.
• W2077897146 countsByYear W20778971462023 @default.
• W2077897146 crossrefType "journal-article" @default.
• W2077897146 hasAuthorship W2077897146A5016224747 @default.
• W2077897146 hasAuthorship W2077897146A5040864474 @default.
• W2077897146 hasAuthorship W2077897146A5045447593 @default.
• W2077897146 hasAuthorship W2077897146A5057839161 @default.
• W2077897146 hasAuthorship W2077897146A5069600944 @default.
• W2077897146 hasAuthorship W2077897146A5076727242 @default.
• W2077897146 hasAuthorship W2077897146A5088788784 @default.
• W2077897146 hasConcept C120770815 @default.
• W2077897146 hasConcept C126322002 @default.
• W2077897146 hasConcept C134018914 @default.
• W2077897146 hasConcept C153461711 @default.
• W2077897146 hasConcept C173803235 @default.
• W2077897146 hasConcept C178790620 @default.
• W2077897146 hasConcept C185592680 @default.
• W2077897146 hasConcept C2776768464 @default.
• W2077897146 hasConcept C2776846068 @default.
• W2077897146 hasConcept C2776919887 @default.
• W2077897146 hasConcept C2777952589 @default.
• W2077897146 hasConcept C2779411790 @default.
• W2077897146 hasConcept C2780419564 @default.
• W2077897146 hasConcept C2781295685 @default.
• W2077897146 hasConcept C517785266 @default.
• W2077897146 hasConcept C519063684 @default.
• W2077897146 hasConcept C519581460 @default.
• W2077897146 hasConcept C71924100 @default.
• W2077897146 hasConcept C83743174 @default.
• W2077897146 hasConcept C84393581 @default.
• W2077897146 hasConcept C98274493 @default.
• W2077897146 hasConceptScore W2077897146C120770815 @default.
• W2077897146 hasConceptScore W2077897146C126322002 @default.
• W2077897146 hasConceptScore W2077897146C134018914 @default.
• W2077897146 hasConceptScore W2077897146C153461711 @default.
• W2077897146 hasConceptScore W2077897146C173803235 @default.
• W2077897146 hasConceptScore W2077897146C178790620 @default.
• W2077897146 hasConceptScore W2077897146C185592680 @default.
• W2077897146 hasConceptScore W2077897146C2776768464 @default.
• W2077897146 hasConceptScore W2077897146C2776846068 @default.
• W2077897146 hasConceptScore W2077897146C2776919887 @default.
• W2077897146 hasConceptScore W2077897146C2777952589 @default.
• W2077897146 hasConceptScore W2077897146C2779411790 @default.
• W2077897146 hasConceptScore W2077897146C2780419564 @default.
• W2077897146 hasConceptScore W2077897146C2781295685 @default.
• W2077897146 hasConceptScore W2077897146C517785266 @default.
• W2077897146 hasConceptScore W2077897146C519063684 @default.

• next