FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077897461> ?p ?o ?g. }

• W2077897461 endingPage "123" @default.
• W2077897461 startingPage "108" @default.
• W2077897461 abstract "This paper describes the design of a study on immunity to reinfection after treatment of children with Schistosoma mansoni infections, the initial observations on transmission that led to the selection of the study population, the effects of treatment, and the results of immunological tests carried out before and at five weeks after treatment. Iietune village in Machakos District, Kenya, was selected on the basis of high prevalence and intensities of infection in a small preliminary survey, a stable population living in a small area amenable to detailed study, and a lack of previous intervention in the area. Subsequent observations over a pretreatment period of one year confirmed that prevalence and intensities of infection among children attending the local primary school were high. This was associated with extensive contact of members of the community with water-bodies shown to contain large numbers of infected snails. Analysis of pretreatment intensities of infection and water contact patterns in the schoolchildren allowed the selection of 129 children showing a broad scatter between: (a) high intensity, low water contact, and predicted to be non-immune, and (b) low intensity, high water contact, and predicted to be immune. These children were treated with oxamniquine, 30 mg/kg in divided doses. Five weeks after treatment, 70% of children showed apparent complete cure, and the over-all reduction in geometric mean egg output was 98·9%. Since these children represented only a small proportion of the whole community, there was no obvious reduction in transmission, as reflected by snail infection rates, during the following five-month period. Thus, we are in a position to determine whether successfully treated children do or do not become reinfected in a high transmission environment in which it will be possible to make direct estimates of exposure. Immunological tests carried out immediately before treatment were consistent with a pattern of high exposure leading to the early expression of immune responses in most infected children. Eosinophil levels were elevated in 61% of the children, all of whom showed detectable levels of antibodies against adult worm and egg antigens, as measured by ELISA. In addition, all patients showed antibodies capable of mediating eosinophil-dependent killing of schistosomula. At five weeks after treatment, eosinophil counts and anti-adult worm antibody levels had risen, whereas anti-egg antibodies remained grossly unchanged. The wide variation in the levels of responses shown by different individuals will allow us to test whether such responses are associated with resistance to reinfection during the follow-up period." @default.
• W2077897461 created "2016-06-24" @default.
• W2077897461 creator A5003869260 @default.
• W2077897461 creator A5010804730 @default.
• W2077897461 creator A5027858273 @default.
• W2077897461 creator A5029604694 @default.
• W2077897461 creator A5043238737 @default.
• W2077897461 creator A5052605456 @default.
• W2077897461 creator A5057436211 @default.
• W2077897461 creator A5071611456 @default.
• W2077897461 date "1984-01-01" @default.
• W2077897461 modified "2023-09-23" @default.
• W2077897461 title "Immunity after treatment of human schistosomiasis mansoni. I. Study design, pretreatment observations and the results of treatment" @default.
• W2077897461 cites W1944184675 @default.
• W2077897461 cites W1964415767 @default.
• W2077897461 cites W1964510112 @default.
• W2077897461 cites W1974980087 @default.
• W2077897461 cites W2000556020 @default.
• W2077897461 cites W2001799097 @default.
• W2077897461 cites W2002671103 @default.
• W2077897461 cites W2014320359 @default.
• W2077897461 cites W2035727712 @default.
• W2077897461 cites W2038139759 @default.
• W2077897461 cites W2042379875 @default.
• W2077897461 cites W2044345630 @default.
• W2077897461 cites W2056712268 @default.
• W2077897461 cites W2075981144 @default.
• W2077897461 cites W2094300672 @default.
• W2077897461 cites W2120204189 @default.
• W2077897461 cites W2150189188 @default.
• W2077897461 cites W2280011123 @default.
• W2077897461 cites W2321933158 @default.
• W2077897461 cites W2337131808 @default.
• W2077897461 cites W2346984537 @default.
• W2077897461 cites W4239482560 @default.
• W2077897461 cites W4327650637 @default.
• W2077897461 doi "https://doi.org/10.1016/0035-9203(84)90190-1" @default.
• W2077897461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6710563" @default.
• W2077897461 hasPublicationYear "1984" @default.
• W2077897461 type Work @default.
• W2077897461 sameAs 2077897461 @default.
• W2077897461 citedByCount "96" @default.
• W2077897461 countsByYear W20778974612012 @default.
• W2077897461 countsByYear W20778974612018 @default.
• W2077897461 countsByYear W20778974612023 @default.
• W2077897461 crossrefType "journal-article" @default.
• W2077897461 hasAuthorship W2077897461A5003869260 @default.
• W2077897461 hasAuthorship W2077897461A5010804730 @default.
• W2077897461 hasAuthorship W2077897461A5027858273 @default.
• W2077897461 hasAuthorship W2077897461A5029604694 @default.
• W2077897461 hasAuthorship W2077897461A5043238737 @default.
• W2077897461 hasAuthorship W2077897461A5052605456 @default.
• W2077897461 hasAuthorship W2077897461A5057436211 @default.
• W2077897461 hasAuthorship W2077897461A5071611456 @default.
• W2077897461 hasConcept C119599485 @default.
• W2077897461 hasConcept C127413603 @default.
• W2077897461 hasConcept C165901193 @default.
• W2077897461 hasConcept C203014093 @default.
• W2077897461 hasConcept C2776026265 @default.
• W2077897461 hasConcept C2776225656 @default.
• W2077897461 hasConcept C2776863245 @default.
• W2077897461 hasConcept C2776908094 @default.
• W2077897461 hasConcept C2777867508 @default.
• W2077897461 hasConcept C2779341262 @default.
• W2077897461 hasConcept C2779744950 @default.
• W2077897461 hasConcept C2908647359 @default.
• W2077897461 hasConcept C2992282259 @default.
• W2077897461 hasConcept C42972112 @default.
• W2077897461 hasConcept C71924100 @default.
• W2077897461 hasConcept C761482 @default.
• W2077897461 hasConcept C86803240 @default.
• W2077897461 hasConcept C8891405 @default.
• W2077897461 hasConcept C99454951 @default.
• W2077897461 hasConceptScore W2077897461C119599485 @default.
• W2077897461 hasConceptScore W2077897461C127413603 @default.
• W2077897461 hasConceptScore W2077897461C165901193 @default.
• W2077897461 hasConceptScore W2077897461C203014093 @default.
• W2077897461 hasConceptScore W2077897461C2776026265 @default.
• W2077897461 hasConceptScore W2077897461C2776225656 @default.
• W2077897461 hasConceptScore W2077897461C2776863245 @default.
• W2077897461 hasConceptScore W2077897461C2776908094 @default.
• W2077897461 hasConceptScore W2077897461C2777867508 @default.
• W2077897461 hasConceptScore W2077897461C2779341262 @default.
• W2077897461 hasConceptScore W2077897461C2779744950 @default.
• W2077897461 hasConceptScore W2077897461C2908647359 @default.
• W2077897461 hasConceptScore W2077897461C2992282259 @default.
• W2077897461 hasConceptScore W2077897461C42972112 @default.
• W2077897461 hasConceptScore W2077897461C71924100 @default.
• W2077897461 hasConceptScore W2077897461C761482 @default.
• W2077897461 hasConceptScore W2077897461C86803240 @default.
• W2077897461 hasConceptScore W2077897461C8891405 @default.
• W2077897461 hasConceptScore W2077897461C99454951 @default.
• W2077897461 hasIssue "1" @default.
• W2077897461 hasLocation W20778974611 @default.
• W2077897461 hasLocation W20778974612 @default.
• W2077897461 hasOpenAccess W2077897461 @default.
• W2077897461 hasPrimaryLocation W20778974611 @default.
• W2077897461 hasRelatedWork W1485239507 @default.

• next