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• W2077897528 abstract "The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the exc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysis suggests that exc-5 is required for the proper placement of cytoskeletal elements at the apical epithelial surface. exc-5 encodes a protein homologous to guanine nucleotide exchange factors and contains motif architecture similar to that of FGD1, which is responsible for faciogenital dysplasia. exc-5 interacts genetically with mig-2, which encodes Rho GTPase. These results suggest that EXC-5 controls the structural organization of the excretory canal by regulating Rho family GTPase activities." @default.
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• W2077897528 date "2001-06-01" @default.
• W2077897528 modified "2023-10-12" @default.
• W2077897528 title "A putative GDP–GTP exchange factor is required for development of the excretory cell in<i>Caenorhabditis elegans</i>" @default.
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• W2077897528 doi "https://doi.org/10.1093/embo-reports/kve110" @default.
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