FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077902145> ?p ?o ?g. }

• W2077902145 endingPage "361" @default.
• W2077902145 startingPage "355" @default.
• W2077902145 abstract "Repeated exposures to anti-cholinesterase compounds induce profound enzyme inhibition and consequent neurotransmitter perturbations. When the result of exposure is an accumulation of neurotransmitter, as it is in the case of exposure to soman, target receptors may respond by compensating for the imbalance by regulating either their number or binding affinity. Recovery of function may further include alterations in receptor systems not themselves a direct target of the toxic compound. Rats were injected with soman (50 μg/kg, sc) three times weekly for 4 weeks and decapitated at intervals ranging from 1 hr to 6 days after the final injection. Synaptic membranes were prepared from hippocampus (HIP), striatum (STR), and cortex (COR) and kinetics of muscarinic cholinergic and GABAergic binding were assessed using [3H]QNB and [3H]muscimol, respectively, as ligands. Soman induced large and persistent decreases in the number of muscarinic receptors in HIP and COR with the surviving receptors being of higher affinity. The number of high affinity GABA receptors decreased in all three regions but returned to near baseline within 3 days after the final soman exposure. These effects are due either to a direct action of soman on the receptors, or a diaschitic response of the receptors to cholinergic excess. Muscarinic cholinergic receptors exhibit a persistent down regulation, and GABA receptors a transient response, to soman administration." @default.
• W2077902145 created "2016-06-24" @default.
• W2077902145 creator A5011364324 @default.
• W2077902145 creator A5066269700 @default.
• W2077902145 creator A5068641535 @default.
• W2077902145 date "1985-12-01" @default.
• W2077902145 modified "2023-09-23" @default.
• W2077902145 title "Soman intoxication alters regional brain muscarinic and GABA receptors" @default.
• W2077902145 cites W1853547351 @default.
• W2077902145 cites W1966080396 @default.
• W2077902145 cites W1969954721 @default.
• W2077902145 cites W1971048984 @default.
• W2077902145 cites W1975722796 @default.
• W2077902145 cites W1978944197 @default.
• W2077902145 cites W1988167573 @default.
• W2077902145 cites W1991913012 @default.
• W2077902145 cites W1992499491 @default.
• W2077902145 cites W2008519666 @default.
• W2077902145 cites W2014774714 @default.
• W2077902145 cites W2033367005 @default.
• W2077902145 cites W2037826750 @default.
• W2077902145 cites W2067049313 @default.
• W2077902145 cites W2068755196 @default.
• W2077902145 cites W2069829859 @default.
• W2077902145 cites W2072229549 @default.
• W2077902145 cites W2080374512 @default.
• W2077902145 cites W2085109583 @default.
• W2077902145 cites W2100520976 @default.
• W2077902145 cites W2128635872 @default.
• W2077902145 cites W2273632874 @default.
• W2077902145 cites W2416203209 @default.
• W2077902145 cites W2442415675 @default.
• W2077902145 cites W2461154227 @default.
• W2077902145 cites W2479553167 @default.
• W2077902145 cites W3022791776 @default.
• W2077902145 cites W3152076632 @default.
• W2077902145 doi "https://doi.org/10.1016/0048-3575(85)90147-6" @default.
• W2077902145 hasPublicationYear "1985" @default.
• W2077902145 type Work @default.
• W2077902145 sameAs 2077902145 @default.
• W2077902145 citedByCount "6" @default.
• W2077902145 crossrefType "journal-article" @default.
• W2077902145 hasAuthorship W2077902145A5011364324 @default.
• W2077902145 hasAuthorship W2077902145A5066269700 @default.
• W2077902145 hasAuthorship W2077902145A5068641535 @default.
• W2077902145 hasConcept C126322002 @default.
• W2077902145 hasConcept C134018914 @default.
• W2077902145 hasConcept C156927020 @default.
• W2077902145 hasConcept C168258287 @default.
• W2077902145 hasConcept C170493617 @default.
• W2077902145 hasConcept C181199279 @default.
• W2077902145 hasConcept C185592680 @default.
• W2077902145 hasConcept C22885893 @default.
• W2077902145 hasConcept C2775910092 @default.
• W2077902145 hasConcept C2776219046 @default.
• W2077902145 hasConcept C2778816929 @default.
• W2077902145 hasConcept C2780266723 @default.
• W2077902145 hasConcept C33789571 @default.
• W2077902145 hasConcept C55493867 @default.
• W2077902145 hasConcept C64123433 @default.
• W2077902145 hasConcept C71924100 @default.
• W2077902145 hasConcept C86803240 @default.
• W2077902145 hasConcept C98274493 @default.
• W2077902145 hasConceptScore W2077902145C126322002 @default.
• W2077902145 hasConceptScore W2077902145C134018914 @default.
• W2077902145 hasConceptScore W2077902145C156927020 @default.
• W2077902145 hasConceptScore W2077902145C168258287 @default.
• W2077902145 hasConceptScore W2077902145C170493617 @default.
• W2077902145 hasConceptScore W2077902145C181199279 @default.
• W2077902145 hasConceptScore W2077902145C185592680 @default.
• W2077902145 hasConceptScore W2077902145C22885893 @default.
• W2077902145 hasConceptScore W2077902145C2775910092 @default.
• W2077902145 hasConceptScore W2077902145C2776219046 @default.
• W2077902145 hasConceptScore W2077902145C2778816929 @default.
• W2077902145 hasConceptScore W2077902145C2780266723 @default.
• W2077902145 hasConceptScore W2077902145C33789571 @default.
• W2077902145 hasConceptScore W2077902145C55493867 @default.
• W2077902145 hasConceptScore W2077902145C64123433 @default.
• W2077902145 hasConceptScore W2077902145C71924100 @default.
• W2077902145 hasConceptScore W2077902145C86803240 @default.
• W2077902145 hasConceptScore W2077902145C98274493 @default.
• W2077902145 hasIssue "3" @default.
• W2077902145 hasLocation W20779021451 @default.
• W2077902145 hasOpenAccess W2077902145 @default.
• W2077902145 hasPrimaryLocation W20779021451 @default.
• W2077902145 hasRelatedWork W1414807662 @default.
• W2077902145 hasRelatedWork W2028908340 @default.
• W2077902145 hasRelatedWork W2035105163 @default.
• W2077902145 hasRelatedWork W2060450776 @default.
• W2077902145 hasRelatedWork W2077902145 @default.
• W2077902145 hasRelatedWork W2094307016 @default.
• W2077902145 hasRelatedWork W2264218955 @default.
• W2077902145 hasRelatedWork W2362823376 @default.
• W2077902145 hasRelatedWork W2392494443 @default.
• W2077902145 hasRelatedWork W2567364378 @default.
• W2077902145 hasVolume "24" @default.
• W2077902145 isParatext "false" @default.
• W2077902145 isRetracted "false" @default.

• next