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• W2077921323 abstract "We have investigated the thermodynamic parameters and binding of a regulatory subunit of cAMP-dependent protein kinase (PKA) to its natural low-molecular-weight ligand, cAMP, and analogues thereof. For analysis of this model system, we compared side-by-side isothermal titration calorimetry (ITC) with surface plasmon resonance (SPR). Both ITC and SPR analyses revealed that binding of the protein to cAMP or its analogues was enthalpically driven and characterised by similar free energy values (ΔG=-9.4 to -10.7 kcal mol-1) for all interactions. Despite the similar affinities, binding of the cyclic nucleotides used here was characterised by significant differences in the contribution of entropy (-TΔS) and enthalpy (ΔH) to ΔG. The comparison of ITC and SPR data for one cAMP analogue further revealed deviations caused by the method. These equilibrium parameters could be complemented by thermodynamic data of the transition state (ΔH≠, ΔG≠, ΔS≠) for both association and dissociation measured by SPR. This direct comparison of ITC and SPR highlights method-specific advantages and drawbacks for thermodynamic analyses of protein/ligand interactions." @default.
• W2077921323 created "2016-06-24" @default.
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• W2077921323 date "2007-01-01" @default.
• W2077921323 modified "2023-09-23" @default.
• W2077921323 title "Comparative thermodynamic analysis of cyclic nucleotide binding to protein kinase A" @default.
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• W2077921323 doi "https://doi.org/10.1515/bc.2007.018" @default.
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