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- W2077922056 abstract "The respiratory depression induced by two μ-opiate morphine and Tyr-d-Ala-Gly-N-Me-Phe-Met(O)-ol (FK-33824), and two δ-agonists Try-d-Ala-Gly-Phe-d-Leu (DADLE) and Tyr-d-Ser-Gly-Phe-Leu-Thr (d-Ser2-Thr6) was studied in rats by using the intracerebroventricular route. The four opioids caused a dose-dependent depression of respiratory frequency down to apnea but high doses of morphine elicited motor activation and seizure activity. FK-33824 was the most potent, followed by DADLE, d-Ser2-Thr6 and morphine. The in vivo apparent pA2 values were determined for naloxone against FK-33824, DADLE and d-Ser2-Thr6. The pA2 value of naloxone interacting with the μ-agonist FK-33824 was significantly lower than those obtained against the two δ-agonists. It is proposed that different types of opiate receptors are involved in the opiate-induced respiratory depression." @default.
- W2077922056 created "2016-06-24" @default.
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- W2077922056 date "1983-02-01" @default.
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- W2077922056 title "Interaction of naloxone with μ- and δ-opioid agonists on the respiration of rats" @default.
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- W2077922056 doi "https://doi.org/10.1016/0014-2999(83)90343-6" @default.
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