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• W2077942645 abstract "Nine usnic acid-amine conjugates were evaluated on murine and human cancer cell lines. The polyamine derivatives showed significant cytotoxicity in L1210 cells. Their activities appeared to be independent of the polyamine transport system (PTS). Indeed, their activities were similar in chinese hamster ovary (CHO) and in the PTS deficient CHO-MG cells. In addition, alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor known to indirectly enhance the activity of the PTS and consequently increase the cytotoxicity of cytotoxic drugs entering cells via the PTS, had no effect on the activity of the polyamine derivatives. The more active derivative (1,8-diaminooctane derivative) displayed similar activities on all cancer cell lines studied and induced apoptosis." @default.
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• W2077942645 date "2008-07-01" @default.
• W2077942645 modified "2023-10-16" @default.
• W2077942645 title "Synthesis and cytotoxic activities of usnic acid derivatives" @default.
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• W2077942645 doi "https://doi.org/10.1016/j.bmc.2008.05.069" @default.
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