Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077945358> ?p ?o ?g. }
- W2077945358 endingPage "122" @default.
- W2077945358 startingPage "116" @default.
- W2077945358 abstract "In this review we use the term spasticity to mean the generation of abnormal patterns of forces that are generated involuntarily. It is clear that spasticity can have both detrimental and beneficial effects on the neuromuscular system of the affected individuals. Muscle spasticity routinely occurs after a spinal cord injury and other neurological disorders. Although often studied as if there was a single mechanism associated with this phenomenon, it is clear that there are multiple mechanisms having both neural and muscular components, particularly when such terms also are applied to other neuromotor disorders. The aims of this review are to describe the neural and muscular adaptations that are associated with spasticity, highlight the major possible mechanisms producing spasticity, and discuss the role of selected pharmacological interventions in controlling spasticity. Spasticity appears to be related to altered membrane channel and receptor properties that are primarily associated with an increase in the excitability of spinal neurons, resulting in abnormal (in the intensity and combination of muscles activated) contractions that are generated involuntarily. While most of the efforts to understand the etiology of spasticity have focused on motoneurons, it is likely that spinal interneurons play a central role as well as the mechanical properties of muscle fibers and associated connective tissues. A number of pharmacological interventions have been used in attempts to suppress spasticity with varying results, but concomitant with suppressed muscle activation, there can be significant side effects including a reduction in the control of movement." @default.
- W2077945358 created "2016-06-24" @default.
- W2077945358 creator A5041686634 @default.
- W2077945358 creator A5068627403 @default.
- W2077945358 date "2012-05-01" @default.
- W2077945358 modified "2023-09-27" @default.
- W2077945358 title "Neurobiological perspective of spasticity as occurs after a spinal cord injury" @default.
- W2077945358 cites W1484841883 @default.
- W2077945358 cites W1549249261 @default.
- W2077945358 cites W1560493734 @default.
- W2077945358 cites W1575447112 @default.
- W2077945358 cites W1580978614 @default.
- W2077945358 cites W1608876571 @default.
- W2077945358 cites W1944654391 @default.
- W2077945358 cites W1963614830 @default.
- W2077945358 cites W1965605977 @default.
- W2077945358 cites W1966537571 @default.
- W2077945358 cites W1975495255 @default.
- W2077945358 cites W1978752891 @default.
- W2077945358 cites W1978836648 @default.
- W2077945358 cites W1978992017 @default.
- W2077945358 cites W1981587254 @default.
- W2077945358 cites W1983434976 @default.
- W2077945358 cites W1986878360 @default.
- W2077945358 cites W1987128684 @default.
- W2077945358 cites W1993434669 @default.
- W2077945358 cites W1999020676 @default.
- W2077945358 cites W1999924211 @default.
- W2077945358 cites W2003381774 @default.
- W2077945358 cites W2006357486 @default.
- W2077945358 cites W2008719375 @default.
- W2077945358 cites W2014467305 @default.
- W2077945358 cites W2016138444 @default.
- W2077945358 cites W2016379224 @default.
- W2077945358 cites W2020206915 @default.
- W2077945358 cites W2021720920 @default.
- W2077945358 cites W2022935391 @default.
- W2077945358 cites W2024839034 @default.
- W2077945358 cites W2027445902 @default.
- W2077945358 cites W2032174469 @default.
- W2077945358 cites W2033122271 @default.
- W2077945358 cites W2034021702 @default.
- W2077945358 cites W2037697517 @default.
- W2077945358 cites W2038679868 @default.
- W2077945358 cites W2039495859 @default.
- W2077945358 cites W2041123280 @default.
- W2077945358 cites W2042497982 @default.
- W2077945358 cites W2045221789 @default.
- W2077945358 cites W2045742968 @default.
- W2077945358 cites W2046272835 @default.
- W2077945358 cites W2048130453 @default.
- W2077945358 cites W2050184259 @default.
- W2077945358 cites W2050746153 @default.
- W2077945358 cites W2052924048 @default.
- W2077945358 cites W2055187509 @default.
- W2077945358 cites W2057010363 @default.
- W2077945358 cites W2060429264 @default.
- W2077945358 cites W2060663619 @default.
- W2077945358 cites W2060951742 @default.
- W2077945358 cites W2062273349 @default.
- W2077945358 cites W2066850919 @default.
- W2077945358 cites W2067230894 @default.
- W2077945358 cites W2069070687 @default.
- W2077945358 cites W2072338371 @default.
- W2077945358 cites W2073357054 @default.
- W2077945358 cites W2075007156 @default.
- W2077945358 cites W2075953000 @default.
- W2077945358 cites W2077008822 @default.
- W2077945358 cites W2078442444 @default.
- W2077945358 cites W2078840957 @default.
- W2077945358 cites W2079952794 @default.
- W2077945358 cites W2083296081 @default.
- W2077945358 cites W2092179920 @default.
- W2077945358 cites W2093787930 @default.
- W2077945358 cites W2093891530 @default.
- W2077945358 cites W2097903277 @default.
- W2077945358 cites W2098118593 @default.
- W2077945358 cites W2101957766 @default.
- W2077945358 cites W2102702733 @default.
- W2077945358 cites W2104490124 @default.
- W2077945358 cites W2107582307 @default.
- W2077945358 cites W2111275676 @default.
- W2077945358 cites W2113390309 @default.
- W2077945358 cites W2116403843 @default.
- W2077945358 cites W2117267014 @default.
- W2077945358 cites W2122715731 @default.
- W2077945358 cites W2124823512 @default.
- W2077945358 cites W2135054768 @default.
- W2077945358 cites W2135894878 @default.
- W2077945358 cites W2135929731 @default.
- W2077945358 cites W2138812804 @default.
- W2077945358 cites W2146182701 @default.
- W2077945358 cites W2156009192 @default.
- W2077945358 cites W2156969997 @default.
- W2077945358 cites W2157848053 @default.
- W2077945358 cites W2170588025 @default.
- W2077945358 cites W2256745758 @default.
- W2077945358 cites W2293991521 @default.