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• W2077950531 abstract "Whether an endobronchial ultrasound (EBUS) is required for transbronchial needle aspiration (TBNA) in the diagnosis of mediastinal masses is currently a disputed subject. Previous studies have demonstrated that EBUS‑TBNA performs better compared to conventional TBNA as it is capable of sampling in real-time compared with conventional TBNA. However, some clinicians consider conventional TBNA to be sufficient for diagnosis. In this meta‑analysis, we evaluated these two methods according to diagnostic yield. A search was conducted through PubMed, Embase and the proceedings of major conferences, for studies comparing TBNA with EBUS‑TBNA in the diagnosis of mediastinal masses. The identified studies were evaluated for publication bias and heterogeneity. The primary outcome was diagnostic yield. Pooled odds ratio (OR) estimated with 95% confidence intervals (CIs) was calculated using the fixed‑effects model. Five studies, including a total of 407 patients, were included in the meta‑analysis. The EBUS‑TBNA arm was associated with a significantly higher OR compared to that of the TBNA arm in terms of diagnostic yield (OR=2.72, 95% CI: 1.72‑4.30, P<0.001). There was no evidence of heterogeneity (I2=0%, P=0.540) or publication bias (Egger's test, P=0.568; Begg‑Mazumdar test, P=0.806). In conclusion, EBUS‑TBNA and conventional TBNA are safe and provide good diagnostic yield in the diagnosis of hilar and mediastinal masses and lymphadenopathies; however, EBUS‑TBNA performs better compared to conventional TBNA, with a shorter aspiration time and higher sensitivity." @default.
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• W2077950531 date "2013-10-23" @default.
• W2077950531 modified "2023-10-18" @default.
• W2077950531 title "Endobronchial ultrasound guided-transbronchial needle aspiration vs. conventional transbronchial needle aspiration in the diagnosis of mediastinal masses: A meta-analysis" @default.
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• W2077950531 doi "https://doi.org/10.3892/mco.2013.206" @default.
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