FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077957736> ?p ?o ?g. }

• W2077957736 abstract "Colorectal cancer (CRC) can be classified according to the level of microsatellite instability (MSI) exhibited by the tumor. The aim of this study was to determine MSI status in CRC from Tunisia and to identify clinical and pathological characteristics of MSI-H tumors. Microsatellite status was determined by polymerase chain reaction amplification using standard markers (BAT25, BAT26, D2S123, D5S346 and D17S250, the Bethesda panel) in 44 CRC cases. Molecular results were correlated with pathological and clinical features. Six CRC cases (13.8%) showed high-level instability (MSI-H), 14 cases had low level instability (MSI-L), and the remainders were stable (MSS). Immunohistochemical analysis showed loss of MSH2 protein in 3 cases among the 6 MSI-H tumors, whereas no silencing of MLH1 or MSH6 was found in any case. Significant differences in age and family history of cancers were observed between MSI-H and MSS/MSI-L groups (p=0.01 and p=0.002). However, statistical analysis showed that there were no significant differences between MSI-H and MSS/MSI-L tumors in terms of tumor location, lymph node involvement and stage of disease. Regarding histological features, MSI-H tumors were more likely to be poorly differentiated (p=0.003), to have a medullary pattern (p=0.005), and to harbor increased numbers of peritumoral lymphocytes (p=0.001). These findings indicate that careful observation of the tumor morphology can assist in the identification of unstable colorectal cancers requiring molecular investigations." @default.
• W2077957736 created "2016-06-24" @default.
• W2077957736 creator A5008725917 @default.
• W2077957736 creator A5012864852 @default.
• W2077957736 creator A5040554046 @default.
• W2077957736 creator A5074927476 @default.
• W2077957736 creator A5077901645 @default.
• W2077957736 creator A5085538476 @default.
• W2077957736 date "2014-02-01" @default.
• W2077957736 modified "2023-09-28" @default.
• W2077957736 title "Clinicopathologic characteristics of colorectal cancer with microsatellite instability" @default.
• W2077957736 cites W1538930506 @default.
• W2077957736 cites W1973231330 @default.
• W2077957736 cites W1987408991 @default.
• W2077957736 cites W1991106907 @default.
• W2077957736 cites W1993883670 @default.
• W2077957736 cites W1995819860 @default.
• W2077957736 cites W1997463754 @default.
• W2077957736 cites W2009384133 @default.
• W2077957736 cites W2013550305 @default.
• W2077957736 cites W2018009295 @default.
• W2077957736 cites W2029243805 @default.
• W2077957736 cites W2033689666 @default.
• W2077957736 cites W2047057598 @default.
• W2077957736 cites W2050717506 @default.
• W2077957736 cites W2050721998 @default.
• W2077957736 cites W2055071377 @default.
• W2077957736 cites W2079825994 @default.
• W2077957736 cites W2082026751 @default.
• W2077957736 cites W2087896732 @default.
• W2077957736 cites W2090109598 @default.
• W2077957736 cites W2100143432 @default.
• W2077957736 cites W2103547637 @default.
• W2077957736 cites W2107972234 @default.
• W2077957736 cites W2124841274 @default.
• W2077957736 cites W2127330908 @default.
• W2077957736 cites W2127951115 @default.
• W2077957736 cites W2128146359 @default.
• W2077957736 cites W2129215293 @default.
• W2077957736 cites W2134786825 @default.
• W2077957736 cites W2164617114 @default.
• W2077957736 cites W2168586177 @default.
• W2077957736 cites W4229815770 @default.
• W2077957736 doi "https://doi.org/10.1016/j.prp.2013.10.004" @default.
• W2077957736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24286815" @default.
• W2077957736 hasPublicationYear "2014" @default.
• W2077957736 type Work @default.
• W2077957736 sameAs 2077957736 @default.
• W2077957736 citedByCount "11" @default.
• W2077957736 countsByYear W20779577362014 @default.
• W2077957736 countsByYear W20779577362015 @default.
• W2077957736 countsByYear W20779577362016 @default.
• W2077957736 countsByYear W20779577362017 @default.
• W2077957736 countsByYear W20779577362020 @default.
• W2077957736 countsByYear W20779577362021 @default.
• W2077957736 crossrefType "journal-article" @default.
• W2077957736 hasAuthorship W2077957736A5008725917 @default.
• W2077957736 hasAuthorship W2077957736A5012864852 @default.
• W2077957736 hasAuthorship W2077957736A5040554046 @default.
• W2077957736 hasAuthorship W2077957736A5074927476 @default.
• W2077957736 hasAuthorship W2077957736A5077901645 @default.
• W2077957736 hasAuthorship W2077957736A5085538476 @default.
• W2077957736 hasConcept C104317684 @default.
• W2077957736 hasConcept C111425858 @default.
• W2077957736 hasConcept C121608353 @default.
• W2077957736 hasConcept C126322002 @default.
• W2077957736 hasConcept C142724271 @default.
• W2077957736 hasConcept C143998085 @default.
• W2077957736 hasConcept C180754005 @default.
• W2077957736 hasConcept C204232928 @default.
• W2077957736 hasConcept C207886595 @default.
• W2077957736 hasConcept C2776674815 @default.
• W2077957736 hasConcept C2779115348 @default.
• W2077957736 hasConcept C2779767149 @default.
• W2077957736 hasConcept C526805850 @default.
• W2077957736 hasConcept C54355233 @default.
• W2077957736 hasConcept C60748783 @default.
• W2077957736 hasConcept C61320498 @default.
• W2077957736 hasConcept C71924100 @default.
• W2077957736 hasConcept C86803240 @default.
• W2077957736 hasConceptScore W2077957736C104317684 @default.
• W2077957736 hasConceptScore W2077957736C111425858 @default.
• W2077957736 hasConceptScore W2077957736C121608353 @default.
• W2077957736 hasConceptScore W2077957736C126322002 @default.
• W2077957736 hasConceptScore W2077957736C142724271 @default.
• W2077957736 hasConceptScore W2077957736C143998085 @default.
• W2077957736 hasConceptScore W2077957736C180754005 @default.
• W2077957736 hasConceptScore W2077957736C204232928 @default.
• W2077957736 hasConceptScore W2077957736C207886595 @default.
• W2077957736 hasConceptScore W2077957736C2776674815 @default.
• W2077957736 hasConceptScore W2077957736C2779115348 @default.
• W2077957736 hasConceptScore W2077957736C2779767149 @default.
• W2077957736 hasConceptScore W2077957736C526805850 @default.
• W2077957736 hasConceptScore W2077957736C54355233 @default.
• W2077957736 hasConceptScore W2077957736C60748783 @default.
• W2077957736 hasConceptScore W2077957736C61320498 @default.
• W2077957736 hasConceptScore W2077957736C71924100 @default.
• W2077957736 hasConceptScore W2077957736C86803240 @default.
• W2077957736 hasLocation W20779577361 @default.
• W2077957736 hasLocation W20779577362 @default.

• next