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• W2077963870 abstract "Live donor liver transplantation (LDLT) mandates conversance in liver anatomy and major hepatectomy. Hepatocellular carcinoma is most reliably treated by hepatectomy.The outcomes of major hepatectomy for hepatocellular carcinoma are influenced by the surgeon's LDLT experience.We collected prospective cohort study data on patient and disease characteristics.Tertiary referral center.A retrospective study was performed on 250 patients who underwent major hepatectomy for hepatocellular carcinoma from January 16, 1996, through December 28, 2001.Overall and disease-free survival and outcomes including blood loss, blood transfusion, and complications.The 3 liver transplantation surgeons (LTSs) performed 102 major hepatectomies; the 4 hepatobiliary and pancreatic surgeons (HBPSs), 148 major hepatectomies. Patients in both groups had similar baseline characteristics. The mean +/- SD blood loss in the LTS and HBPS groups was 1.36 +/- 1.37 and 2.21 +/- 2.40 L, respectively (P<.001). The mean +/- SD blood transfusion in the LTS and HBPS groups was 0.27 +/- 0.82 and 0.51 +/- 0.94 L, respectively (P =.001). Fewer patients in the LTS group required blood transfusion (17/102 [16.7%]; HBPS group, 57/148 [38.5%]; P<.001). We found no difference in overall and disease-free survival between the groups. The median overall survival was 55.8 months for the nontransfused group, and 34.3 months for the transfused group (P =.06). Median disease-free survival was 16.1 months for the nontransfused group compared with 12.4 months for the transfused group (P =.25). Cox regression multivariate analysis showed that transfusion, cirrhosis, and venous invasion worsened overall survival. Venous invasion, cirrhosis, and tumor size adversely affected disease-free survival.The LTS group lost less blood and required less blood transfusions than the HBPS group. Blood transfusion worsened overall survival. The significantly lower blood transfusion requirement of the LTS group contributes to a potential advantage in their overall survival." @default.
• W2077963870 created "2016-06-24" @default.
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• W2077963870 date "2003-03-01" @default.
• W2077963870 modified "2023-10-17" @default.
• W2077963870 title "Value of Live Donor Liver Transplantation Experience in Major Hepatectomy for Hepatocellular Carcinoma" @default.
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• W2077963870 doi "https://doi.org/10.1001/archsurg.138.3.265" @default.
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