Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077967524> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2077967524 endingPage "213" @default.
- W2077967524 startingPage "213" @default.
- W2077967524 abstract "Alzheimer's disease (AD) is considered the most harmful form of dementia in the elderly population. At present, there are no effective treatments and this is likely due to the incomplete understanding of the pathophysiology. Recent data indicate that synaptic dysfunction could be a central element of AD pathophysiology. It was found that a synaptic breakdown is an early event that heralds neuronal degeneration. Transcranial magnetic stimulation (TMS) has been recently introduced as a novel approach to identify the early signatures of synaptic dysfunction characterizing AD pathophysiology. In this chapter, we review the new neurophysiologic signatures of AD that have been emphasized by TMS studies. We show how TMS measurement of neuroplasticity identified long-term potentiation (LTP)-like cortical plasticity as a key element of AD synaptic dysfunction. These measurements are useful to increase the accuracy of differential diagnosis, predict disease progression, and anticipate response to therapy. Moreover, enhancing neuroplasticity holds as a promising therapeutic approach to improve cognition in AD. In recent years, studies showed treatments with multiple sessions of rTMS can influence cognition in people with neurodegenerative diseases. In the second part of this chapter, we also consider novel therapeutic approaches based on the clinical use of rTMS." @default.
- W2077967524 created "2016-06-24" @default.
- W2077967524 creator A5008252393 @default.
- W2077967524 creator A5021420538 @default.
- W2077967524 creator A5029520152 @default.
- W2077967524 creator A5029571817 @default.
- W2077967524 creator A5072415195 @default.
- W2077967524 creator A5075477128 @default.
- W2077967524 date "2000-05-01" @default.
- W2077967524 modified "2023-09-26" @default.
- W2077967524 title "Mitochondrial abnormalities in Alzheimer disease" @default.
- W2077967524 doi "https://doi.org/10.1016/s0197-4580(00)83289-3" @default.
- W2077967524 hasPublicationYear "2000" @default.
- W2077967524 type Work @default.
- W2077967524 sameAs 2077967524 @default.
- W2077967524 citedByCount "5" @default.
- W2077967524 countsByYear W20779675242019 @default.
- W2077967524 countsByYear W20779675242022 @default.
- W2077967524 crossrefType "journal-article" @default.
- W2077967524 hasAuthorship W2077967524A5008252393 @default.
- W2077967524 hasAuthorship W2077967524A5021420538 @default.
- W2077967524 hasAuthorship W2077967524A5029520152 @default.
- W2077967524 hasAuthorship W2077967524A5029571817 @default.
- W2077967524 hasAuthorship W2077967524A5072415195 @default.
- W2077967524 hasAuthorship W2077967524A5075477128 @default.
- W2077967524 hasConcept C10162356 @default.
- W2077967524 hasConcept C126322002 @default.
- W2077967524 hasConcept C15744967 @default.
- W2077967524 hasConcept C169760540 @default.
- W2077967524 hasConcept C170493617 @default.
- W2077967524 hasConcept C24998067 @default.
- W2077967524 hasConcept C25274449 @default.
- W2077967524 hasConcept C2778581513 @default.
- W2077967524 hasConcept C2779134260 @default.
- W2077967524 hasConcept C2779483572 @default.
- W2077967524 hasConcept C2908647359 @default.
- W2077967524 hasConcept C47611674 @default.
- W2077967524 hasConcept C71924100 @default.
- W2077967524 hasConcept C98229152 @default.
- W2077967524 hasConcept C99454951 @default.
- W2077967524 hasConceptScore W2077967524C10162356 @default.
- W2077967524 hasConceptScore W2077967524C126322002 @default.
- W2077967524 hasConceptScore W2077967524C15744967 @default.
- W2077967524 hasConceptScore W2077967524C169760540 @default.
- W2077967524 hasConceptScore W2077967524C170493617 @default.
- W2077967524 hasConceptScore W2077967524C24998067 @default.
- W2077967524 hasConceptScore W2077967524C25274449 @default.
- W2077967524 hasConceptScore W2077967524C2778581513 @default.
- W2077967524 hasConceptScore W2077967524C2779134260 @default.
- W2077967524 hasConceptScore W2077967524C2779483572 @default.
- W2077967524 hasConceptScore W2077967524C2908647359 @default.
- W2077967524 hasConceptScore W2077967524C47611674 @default.
- W2077967524 hasConceptScore W2077967524C71924100 @default.
- W2077967524 hasConceptScore W2077967524C98229152 @default.
- W2077967524 hasConceptScore W2077967524C99454951 @default.
- W2077967524 hasLocation W20779675241 @default.
- W2077967524 hasOpenAccess W2077967524 @default.
- W2077967524 hasPrimaryLocation W20779675241 @default.
- W2077967524 hasRelatedWork W1979470367 @default.
- W2077967524 hasRelatedWork W2059535453 @default.
- W2077967524 hasRelatedWork W2076208297 @default.
- W2077967524 hasRelatedWork W2083920471 @default.
- W2077967524 hasRelatedWork W2098043462 @default.
- W2077967524 hasRelatedWork W2749467790 @default.
- W2077967524 hasRelatedWork W2951719254 @default.
- W2077967524 hasRelatedWork W3007425223 @default.
- W2077967524 hasRelatedWork W4225725207 @default.
- W2077967524 hasRelatedWork W4328050435 @default.
- W2077967524 hasVolume "21" @default.
- W2077967524 isParatext "false" @default.
- W2077967524 isRetracted "false" @default.
- W2077967524 magId "2077967524" @default.
- W2077967524 workType "article" @default.