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• W2077970533 startingPage "432" @default.
• W2077970533 abstract "Objective: Transforming growth factor beta (TGFβ)-activated kinase 1 (TAK1) is a MAP kinase kinase kinase involved in numerous signalling pathways and is strongly implicated in cardiac hypertrophy and heart failure. TGFβ is also associated with hypertension and heart disease, and evidence suggests that TGFβ1 and TAK1 act together in a cardiac stress signalling pathway. Canonical TGFβ signalling is mediated through Smad transcription factors, but TGFβ can also rapidly activate TAK1. The activation of the Smad cascade is well characterised, but little is known about how TAK1 is activated in response to TGFβ, and no direct link between any MAPK kinase pathway and the TGFβ receptors has yet been established. Since TAK1 is activated by TGFβ within 1 min in cardiomyocytes, we hypothesised there might be a direct interaction between TAK1 and one of the TGFβ receptors." @default.
• W2077970533 created "2016-06-24" @default.
• W2077970533 creator A5054107714 @default.
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• W2077970533 date "2006-02-01" @default.
• W2077970533 modified "2023-10-18" @default.
• W2077970533 title "A direct interaction between TGFβ activated kinase 1 and the TGFβ type II receptor: Implications for TGFβ signalling and cardiac hypertrophy" @default.
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• W2077970533 doi "https://doi.org/10.1016/j.cardiores.2005.11.007" @default.
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