FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077973373> ?p ?o ?g. }

• W2077973373 endingPage "213" @default.
• W2077973373 startingPage "204" @default.
• W2077973373 abstract "Abstract: Studies in humans and in animal models have demonstrated that the receptor‐dependent actions of 1,25‐dihydroxyvitamin D are required for normal skeletal growth and maturation. Investigations were undertaken to address which consequences of vitamin D receptor deficiency are a direct result of impaired receptor‐dependent hormone actions versus being due to metabolic changes. Vitamin D receptor (VDR) knockout mice were therefore generated. Investigations were performed in mice with abnormal mineral ion homeostasis, as well as in mice in which the development of abnormal mineral ion homeostasis was prevented by dietary means. VDR null mice had hypocalcemia, hyperparathyroidism, and hypophosphatemia in the first month of life. Rickets and osteomalacia are observed as well. Institution of a high‐calcium, high‐phosphorus, lactose‐supplemented diet by the third week of life prevents abnormalities in mineral ion homeostasis. The bones of the VDR null mice with normal mineral ion homeostasis are indistinguishable from those of their wild‐type littermates. The rachitic changes in the growth plates are also prevented by maintenance of normal mineral ion homeostasis. Investigations into the pathophysiological basis for the growth plate abnormalities in the VDR null mice with abnormal mineral ion homeostasis demonstrated that impaired apoptosis of hypertrophic chondrocytes due to hypophosphatemia was the cause of rachitic changes. Studies investigating the cause of the alopecia demonstrate novel ligand‐independent VDR actions in the keratinocyte. The skeletal effects of VDR ablation are therefore indirect and reflect absence of ligand‐dependent receptor actions in the intestine. In contrast, the cutaneous phenotype of VDR ablation is a direct consequence of absence of ligand‐independent VDR actions in epidermal keratinocytes." @default.
• W2077973373 created "2016-06-24" @default.
• W2077973373 creator A5058515618 @default.
• W2077973373 date "2006-04-01" @default.
• W2077973373 modified "2023-09-27" @default.
• W2077973373 title "Mechanism of Vitamin D Receptor Action" @default.
• W2077973373 cites W1882211948 @default.
• W2077973373 cites W1967380126 @default.
• W2077973373 cites W1972829107 @default.
• W2077973373 cites W1990935283 @default.
• W2077973373 cites W1993171908 @default.
• W2077973373 cites W1999040357 @default.
• W2077973373 cites W2007492637 @default.
• W2077973373 cites W2009900140 @default.
• W2077973373 cites W2017019792 @default.
• W2077973373 cites W2018381121 @default.
• W2077973373 cites W2018809127 @default.
• W2077973373 cites W2021206718 @default.
• W2077973373 cites W2024160556 @default.
• W2077973373 cites W2024855291 @default.
• W2077973373 cites W2036957298 @default.
• W2077973373 cites W2041766623 @default.
• W2077973373 cites W2052417817 @default.
• W2077973373 cites W2064683965 @default.
• W2077973373 cites W2065463926 @default.
• W2077973373 cites W2072256043 @default.
• W2077973373 cites W2073026049 @default.
• W2077973373 cites W2073870011 @default.
• W2077973373 cites W2078862807 @default.
• W2077973373 cites W2080016438 @default.
• W2077973373 cites W2087333134 @default.
• W2077973373 cites W2088137004 @default.
• W2077973373 cites W2091234876 @default.
• W2077973373 cites W2094731386 @default.
• W2077973373 cites W2097191932 @default.
• W2077973373 cites W2097724305 @default.
• W2077973373 cites W2139467936 @default.
• W2077973373 cites W2139996507 @default.
• W2077973373 cites W2158579288 @default.
• W2077973373 cites W2316468721 @default.
• W2077973373 cites W4236608613 @default.
• W2077973373 cites W4243303468 @default.
• W2077973373 doi "https://doi.org/10.1196/annals.1346.026" @default.
• W2077973373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16831920" @default.
• W2077973373 hasPublicationYear "2006" @default.
• W2077973373 type Work @default.
• W2077973373 sameAs 2077973373 @default.
• W2077973373 citedByCount "100" @default.
• W2077973373 countsByYear W20779733732012 @default.
• W2077973373 countsByYear W20779733732013 @default.
• W2077973373 countsByYear W20779733732014 @default.
• W2077973373 countsByYear W20779733732015 @default.
• W2077973373 countsByYear W20779733732016 @default.
• W2077973373 countsByYear W20779733732017 @default.
• W2077973373 countsByYear W20779733732018 @default.
• W2077973373 countsByYear W20779733732019 @default.
• W2077973373 countsByYear W20779733732020 @default.
• W2077973373 countsByYear W20779733732021 @default.
• W2077973373 countsByYear W20779733732022 @default.
• W2077973373 countsByYear W20779733732023 @default.
• W2077973373 crossrefType "journal-article" @default.
• W2077973373 hasAuthorship W2077973373A5058515618 @default.
• W2077973373 hasConcept C124490489 @default.
• W2077973373 hasConcept C126322002 @default.
• W2077973373 hasConcept C134018914 @default.
• W2077973373 hasConcept C170493617 @default.
• W2077973373 hasConcept C179639408 @default.
• W2077973373 hasConcept C182704531 @default.
• W2077973373 hasConcept C185592680 @default.
• W2077973373 hasConcept C2776489590 @default.
• W2077973373 hasConcept C2778049618 @default.
• W2077973373 hasConcept C2778573388 @default.
• W2077973373 hasConcept C2781208988 @default.
• W2077973373 hasConcept C519063684 @default.
• W2077973373 hasConcept C63645605 @default.
• W2077973373 hasConcept C71924100 @default.
• W2077973373 hasConcept C86803240 @default.
• W2077973373 hasConceptScore W2077973373C124490489 @default.
• W2077973373 hasConceptScore W2077973373C126322002 @default.
• W2077973373 hasConceptScore W2077973373C134018914 @default.
• W2077973373 hasConceptScore W2077973373C170493617 @default.
• W2077973373 hasConceptScore W2077973373C179639408 @default.
• W2077973373 hasConceptScore W2077973373C182704531 @default.
• W2077973373 hasConceptScore W2077973373C185592680 @default.
• W2077973373 hasConceptScore W2077973373C2776489590 @default.
• W2077973373 hasConceptScore W2077973373C2778049618 @default.
• W2077973373 hasConceptScore W2077973373C2778573388 @default.
• W2077973373 hasConceptScore W2077973373C2781208988 @default.
• W2077973373 hasConceptScore W2077973373C519063684 @default.
• W2077973373 hasConceptScore W2077973373C63645605 @default.
• W2077973373 hasConceptScore W2077973373C71924100 @default.
• W2077973373 hasConceptScore W2077973373C86803240 @default.
• W2077973373 hasIssue "1" @default.
• W2077973373 hasLocation W20779733731 @default.
• W2077973373 hasLocation W20779733732 @default.
• W2077973373 hasOpenAccess W2077973373 @default.
• W2077973373 hasPrimaryLocation W20779733731 @default.
• W2077973373 hasRelatedWork W1981720126 @default.

• next