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• W2077974749 abstract "<h3>Abstract</h3> <b>Objective</b> To determine whether measuring monoclonal bands (M component) in serum should be part of the investigation of patients referred to osteoporosis clinics. <b>Design</b> Retrospective, cross sectional, observational study. <b>Setting</b> Referral centre for osteoporosis in a university hospital, Denmark. <b>Participants</b> 799 people (685 women) aged 19 to 94 years newly referred with suspected osteoporosis. <b>Main outcome measures</b> Proportion of patients fulfilling the Nordic Myeloma Study Group definition for target condition and proportion of patients with other important haematological conditions. <b>Results</b> 4.9% (18 of 366) of patients with osteoporosis and 2.2% (9 of 408) of patients without osteoporosis had M component in serum (χ² = 3.66, P = 0.04). Multiple myeloma was diagnosed in three patients with osteoporosis (absolute risk 0.8%, 95% confidence interval 0.11% to 1.7%). The relative risk of multiple myeloma in patients presenting with osteoporosis was 75 (10 to 160). As a diagnostic test for multiple myeloma in patients with osteoporosis, M component in serum had a specificity of 95.0% and a positive predictive value of 17.6%. 122 blood electrophoreses were carried out for each case of multiple myeloma diagnosed. All patients with multiple myeloma had a history of fragility fractures. If lymphoma was included as a target condition, the specificity increased to 95.3% and the positive predictive value increased to 23.5%. Monoclonal gammopathy of undetermined significance was diagnosed in 13 (3.6%) participants with osteoporosis and in eight (2.0%) participants with normal bone mineral density or osteopenia. <b>Conclusions</b> Patients presenting with osteoporosis should be tested for M component in serum, as 1 in 20 patients with newly diagnosed osteoporosis had multiple myeloma or monoclonal gammopathy of undetermined significance." @default.
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• W2077974749 date "2005-03-14" @default.
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• W2077974749 title "Utility of testing for monoclonal bands in serum of patients with suspected osteoporosis: retrospective, cross sectional study" @default.
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• W2077974749 doi "https://doi.org/10.1136/bmj.38376.401701.8f" @default.
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