Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077976596> ?p ?o ?g. }
- W2077976596 endingPage "30" @default.
- W2077976596 startingPage "19" @default.
- W2077976596 abstract "The testis exhibits a distinctive form of immune privilege to protect the germ cells from the host immune attack. The property of testicular immune privilege was originally attributed to the blood-testis barrier in the seminiferous epithelium, which sequesters antigens. Recent studies have uncovered several levels of immune control besides the blood-testis barrier involved in the privilege of the testis, including the mechanisms of immune tolerance, reduced immune activation, localized active immunosuppression and antigen-specific immunoregulation. The somatic cells of the testis, especially Sertoli cells, play a key role in regulating the testicular immune privileged status. The constitutive expression of anti-inflammatory factors in the testis by somatic cells is essential for local immunosuppression. Growing evidence shows that androgens orchestrate the inhibition of proinflammatory factors and shift cytokine balance toward a tolerogenic environment. Disruption of these protective mechanisms, which may be caused by trauma, infection and genetic factors, can lead to orchitis and infertility. This review article highlights the unique immune environment of the testis, particularly focuses on the regulation of testicular immune privilege." @default.
- W2077976596 created "2016-06-24" @default.
- W2077976596 creator A5021671129 @default.
- W2077976596 creator A5076527416 @default.
- W2077976596 creator A5078147769 @default.
- W2077976596 date "2011-01-29" @default.
- W2077976596 modified "2023-10-18" @default.
- W2077976596 title "Mechanisms of testicular immune privilege" @default.
- W2077976596 cites W1492469697 @default.
- W2077976596 cites W1523768703 @default.
- W2077976596 cites W1646925026 @default.
- W2077976596 cites W1661544713 @default.
- W2077976596 cites W1672465829 @default.
- W2077976596 cites W1803601143 @default.
- W2077976596 cites W1864268059 @default.
- W2077976596 cites W1885973123 @default.
- W2077976596 cites W1913574441 @default.
- W2077976596 cites W1921382807 @default.
- W2077976596 cites W1970277802 @default.
- W2077976596 cites W1975929837 @default.
- W2077976596 cites W1977160855 @default.
- W2077976596 cites W1987388019 @default.
- W2077976596 cites W1988564839 @default.
- W2077976596 cites W1991048305 @default.
- W2077976596 cites W1991173823 @default.
- W2077976596 cites W1991594550 @default.
- W2077976596 cites W1994998802 @default.
- W2077976596 cites W1996721010 @default.
- W2077976596 cites W1998249081 @default.
- W2077976596 cites W1998533172 @default.
- W2077976596 cites W1999987813 @default.
- W2077976596 cites W2001696564 @default.
- W2077976596 cites W2002733542 @default.
- W2077976596 cites W2003185176 @default.
- W2077976596 cites W2005793050 @default.
- W2077976596 cites W2011614269 @default.
- W2077976596 cites W2011654163 @default.
- W2077976596 cites W2012443958 @default.
- W2077976596 cites W2013086716 @default.
- W2077976596 cites W2017289418 @default.
- W2077976596 cites W2021800255 @default.
- W2077976596 cites W2022875228 @default.
- W2077976596 cites W2023455887 @default.
- W2077976596 cites W2025381136 @default.
- W2077976596 cites W2026615583 @default.
- W2077976596 cites W2030785705 @default.
- W2077976596 cites W2035826801 @default.
- W2077976596 cites W2036244077 @default.
- W2077976596 cites W2036829144 @default.
- W2077976596 cites W2042089641 @default.
- W2077976596 cites W2047096573 @default.
- W2077976596 cites W2048096874 @default.
- W2077976596 cites W2049018791 @default.
- W2077976596 cites W2049108052 @default.
- W2077976596 cites W205568925 @default.
- W2077976596 cites W2056010443 @default.
- W2077976596 cites W2057432063 @default.
- W2077976596 cites W2058674842 @default.
- W2077976596 cites W2062084187 @default.
- W2077976596 cites W2062281916 @default.
- W2077976596 cites W2063919732 @default.
- W2077976596 cites W2064160679 @default.
- W2077976596 cites W2064416626 @default.
- W2077976596 cites W2064488645 @default.
- W2077976596 cites W2067534355 @default.
- W2077976596 cites W2071709107 @default.
- W2077976596 cites W2074649306 @default.
- W2077976596 cites W2074685588 @default.
- W2077976596 cites W2076229621 @default.
- W2077976596 cites W2078435986 @default.
- W2077976596 cites W2079122334 @default.
- W2077976596 cites W2081777761 @default.
- W2077976596 cites W2083299440 @default.
- W2077976596 cites W2086615330 @default.
- W2077976596 cites W2087535382 @default.
- W2077976596 cites W2091743163 @default.
- W2077976596 cites W2093750841 @default.
- W2077976596 cites W2098400794 @default.
- W2077976596 cites W2103830724 @default.
- W2077976596 cites W2104974259 @default.
- W2077976596 cites W2105378583 @default.
- W2077976596 cites W2107382596 @default.
- W2077976596 cites W2107416858 @default.
- W2077976596 cites W2109452881 @default.
- W2077976596 cites W2112358444 @default.
- W2077976596 cites W2115701666 @default.
- W2077976596 cites W2117665832 @default.
- W2077976596 cites W2117755788 @default.
- W2077976596 cites W2122742871 @default.
- W2077976596 cites W2123865901 @default.
- W2077976596 cites W2126073113 @default.
- W2077976596 cites W2131038625 @default.
- W2077976596 cites W2131524018 @default.
- W2077976596 cites W2131950300 @default.
- W2077976596 cites W2133140655 @default.
- W2077976596 cites W2144063221 @default.
- W2077976596 cites W2145423989 @default.
- W2077976596 cites W2149014007 @default.