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• W2077978674 abstract "<h2>Summary</h2> Sixty-seven young children who had been inoculated with <i>B. pertussis</i> vaccine (Sauer) and seventy children who had not been inoculated were intimately exposed to whooping cough in a child-caring institution. The ages and conditions of exposure were comparable for both groups. Of the 67 inoculated children, 24 or 35.8 per cent developed whooping cough, whereas of the 70 control children, 58 or 82.8 per cent were attacked. The severity of the disease was definitely milder in the inoculated group. Three different dosages of the vaccine were employed, namely, 80, 110, and 130 billion organisms. Seven children received the 80 billion dosage; 21, the 110 billion; and 39, the 130 billion dosage. The incidence of whooping cough was considerably lower among those receiving 130 billion organisms, 20 per cent of the children having developed the disease as compared with 57 per cent in the 110 billion group and 57 per cent in the 80 billion group. It should be added that, although the incidence of whooping cough in the latter groups was not greatly reduced, the course of the disease was milder in these children as compared with the children not inoculated. Two hundred seventy-one children were discharged from the institution from four months to four years prior to the epidemic; 120 had been been inoculated. The ages, as well as the average number of months which elapsed since discharge, were comparable for both groups. Two, or 1.7 per cent, of the inoculated children contracted whooping cough outside of the institution, whereas 22, or 14.6 per cent, of the control children developed the disease. The high degree of effectiveness of the 80 billion dosage among these children was probably due to the fact that the exposures were not intensive. Under conditions of household exposure, the 80 billion dosage frequently does not prevent whooping cough although it may bring about a modification of the course of the disease. Inasmuch as household exposure may be comparable to that which existed in the wards of the institution, it is therefore probable that the 130 billion dosage would prove more effective than the usual 80 billion dosage in preventing whooping cough among children intimately exposed to this disease in their homes." @default.
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• W2077978674 date "1940-11-01" @default.
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• W2077978674 title "The value of B. pertussis vaccine in the prevention of whooping cough in a child-caring institution" @default.
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• W2077978674 doi "https://doi.org/10.1016/s0022-3476(40)80130-3" @default.
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