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• W2077989831 abstract "Objective MicroRNAs (miRNAs, miRs) are non-coding RNAs which post-transcriptionally regulate mRNA synthesis. Data regarding the expression and clinical relevance of miRNAs and the miRNA-regulating machinery in ovarian carcinoma has been rapidly expanding in recent years. This review presents current knowledge in this area. Methods PubMed search was undertaken using the terms ‘ovarian’ and ‘microRNA’. Results A total of 492 papers were identified, of which approximately 100 were publications in English focusing exclusively or partly on clinical ovarian carcinoma specimens. These studies have identified multiple miRNAs with a potential role in the diagnosis, biology and progression of ovarian carcinoma, as well as on predicting chemoresponse and determining prognosis. Conclusions The presented data support a clinical role for miRNAs in ovarian carcinoma and suggest that miRNA-regulated pathways may be of relevance for novel therapeutics. Novel technologies offer new possibilities for wide-scale miRNA-based classification of OC. Further genomic research focusing on larger series of tumors of similar histological type in combination with experimental approaches is likely to expand our understanding of the role of miRNAs in this cancer." @default.
• W2077989831 created "2016-06-24" @default.
• W2077989831 creator A5041434650 @default.
• W2077989831 creator A5077653892 @default.
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• W2077989831 date "2014-06-01" @default.
• W2077989831 modified "2023-10-14" @default.
• W2077989831 title "The clinical and diagnostic role of microRNAs in ovarian carcinoma" @default.
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• W2077989831 doi "https://doi.org/10.1016/j.ygyno.2014.03.575" @default.
• W2077989831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24713546" @default.
• W2077989831 hasPublicationYear "2014" @default.
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