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- W2077991298 abstract "The effects of a copolymer of monoclonal anti-idiotype (7B7.10) with keyhole limpet heamocyanin (KLH), designated 7-K, on an ongoing immune response were investigated. It was found that the response could be diverted to the production of higher of antip-azobenzenearsnate (Ar) antibodies, of which nearly 100% carry an intrastrain crossreactive idiotype (CRIA). The effect was observed only in mice that had received a prreinoculation of KLH-Ar, or KLH plus bovine gamma globulin-Ar (BGG-Ar). The effect was also observd, however, when cross-linked 7B7.10 was mixed, rather than conjugated with KLH, suggesting that the role of KLH was to induce the production of a B-cell growth factor. Cross-linked 7B7.10 was not effective in the absence of KLH. A primary inculation of 7-K together with KLH-Ar did not result ini significant suppression or enhancement of CRIA. Also, pre-inoculation of 7-K alone did not suppress a subsequent idiotypic response to KLH-Ar, whereas monomeric anti-Id was suppressive. This supports a possible role for the unmodified Fc segment in the suppressive mechanism. In mice primed with KLH-Ar, before administration of 7-K, CRIA molecules lacking anti-Ar activity were present in very low concentrations in the immune sera. The methods described permit the reproducible production of large amounts of CRIA anti-Ar antibodies." @default.
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- W2077991298 date "1987-02-01" @default.
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- W2077991298 title "Enhancement and Suppression of an Intrastrain Cross-Reactive Idiotype" @default.
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- W2077991298 doi "https://doi.org/10.1111/j.1365-3083.1987.tb01065.x" @default.
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