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- W2077993168 abstract "By definition central respiratory chemoreceptors (CRCs) are cells that are sensitive to changes in brain PCO2 or pH and contribute to the stimulation of breathing elicited by hypercapnia or metabolic acidosis. CO2 most likely works by lowering pH. The pertinent proton receptors have not been identified and may be ion channels. CRCs are probably neurons but may also include acid-sensitive glia and vascular cells that communicate with neurons via paracrine mechanisms. Retrotrapezoid nucleus (RTN) neurons are the most completely characterized CRCs. Their high sensitivity to CO2 in vivo presumably relies on their intrinsic acid sensitivity, excitatory inputs from the carotid bodies and brain regions such as raphe and hypothalamus, and facilitating influences from neighboring astrocytes. RTN neurons are necessary for the respiratory network to respond to CO2 during the perinatal period and under anesthesia. In conscious adults, RTN neurons contribute to an unknown degree to the pH-dependent regulation of breathing rate, inspiratory, and expiratory activity. The abnormal prenatal development of RTN neurons probably contributes to the congenital central hypoventilation syndrome. Other CRCs presumably exist, but the supportive evidence is less complete. The proposed locations of these CRCs are the medullary raphe, the nucleus tractus solitarius, the ventrolateral medulla, the fastigial nucleus, and the hypothalamus. Several wake-promoting systems (serotonergic and catecholaminergic neurons, orexinergic neurons) are also putative CRCs. Their contribution to central respiratory chemoreception may be behavior dependent or vary according to the state of vigilance. J. Comp. Neurol. 518:3883–3906, 2010. © 2010 Wiley-Liss, Inc." @default.
- W2077993168 created "2016-06-24" @default.
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- W2077993168 date "2010-05-20" @default.
- W2077993168 modified "2023-10-10" @default.
- W2077993168 title "Central respiratory chemoreception" @default.
- W2077993168 cites W1482320560 @default.
- W2077993168 cites W1484834707 @default.
- W2077993168 cites W1488974332 @default.
- W2077993168 cites W1504261214 @default.
- W2077993168 cites W1510968844 @default.
- W2077993168 cites W1521516049 @default.
- W2077993168 cites W1537814019 @default.
- W2077993168 cites W1543876289 @default.
- W2077993168 cites W1567135553 @default.
- W2077993168 cites W1574095484 @default.
- W2077993168 cites W1586280139 @default.
- W2077993168 cites W1591288342 @default.
- W2077993168 cites W1608846710 @default.
- W2077993168 cites W1626312819 @default.
- W2077993168 cites W1670158471 @default.
- W2077993168 cites W1798638058 @default.
- W2077993168 cites W1860512920 @default.
- W2077993168 cites W1869943391 @default.
- W2077993168 cites W1903603555 @default.
- W2077993168 cites W1923525643 @default.
- W2077993168 cites W1933463815 @default.
- W2077993168 cites W1963709170 @default.
- W2077993168 cites W1963936141 @default.
- W2077993168 cites W1968916283 @default.
- W2077993168 cites W1970412575 @default.
- W2077993168 cites W1970986757 @default.
- W2077993168 cites W1971288017 @default.
- W2077993168 cites W1971320230 @default.
- W2077993168 cites W1976132208 @default.
- W2077993168 cites W1977697369 @default.
- W2077993168 cites W1978496762 @default.
- W2077993168 cites W1980005901 @default.
- W2077993168 cites W1980182361 @default.
- W2077993168 cites W1980925491 @default.
- W2077993168 cites W1982910988 @default.
- W2077993168 cites W1983782150 @default.
- W2077993168 cites W1985455923 @default.
- W2077993168 cites W1985632319 @default.
- W2077993168 cites W1985791251 @default.
- W2077993168 cites W1987257468 @default.
- W2077993168 cites W1989174024 @default.
- W2077993168 cites W1990898009 @default.
- W2077993168 cites W1990953173 @default.
- W2077993168 cites W1991766559 @default.
- W2077993168 cites W1992693738 @default.
- W2077993168 cites W1992733441 @default.
- W2077993168 cites W1993893814 @default.
- W2077993168 cites W1995579155 @default.
- W2077993168 cites W1996476015 @default.
- W2077993168 cites W1997351859 @default.
- W2077993168 cites W2003549182 @default.
- W2077993168 cites W2003720977 @default.
- W2077993168 cites W2003827347 @default.
- W2077993168 cites W2006219353 @default.
- W2077993168 cites W2007105648 @default.
- W2077993168 cites W2007311340 @default.
- W2077993168 cites W2007377332 @default.
- W2077993168 cites W2007404429 @default.
- W2077993168 cites W2007569082 @default.
- W2077993168 cites W2007957058 @default.
- W2077993168 cites W2011781890 @default.
- W2077993168 cites W2012355941 @default.
- W2077993168 cites W2012880123 @default.
- W2077993168 cites W2013711061 @default.
- W2077993168 cites W2014671181 @default.
- W2077993168 cites W2015693606 @default.
- W2077993168 cites W2018970302 @default.
- W2077993168 cites W2020662075 @default.
- W2077993168 cites W2021727710 @default.
- W2077993168 cites W2022948456 @default.
- W2077993168 cites W2023809428 @default.
- W2077993168 cites W2025687881 @default.
- W2077993168 cites W2026892351 @default.
- W2077993168 cites W2027429673 @default.
- W2077993168 cites W2027617326 @default.
- W2077993168 cites W2028121897 @default.
- W2077993168 cites W2028164933 @default.
- W2077993168 cites W2029525397 @default.
- W2077993168 cites W2030155635 @default.
- W2077993168 cites W2032463924 @default.
- W2077993168 cites W2035415038 @default.
- W2077993168 cites W2035648691 @default.
- W2077993168 cites W2036902033 @default.
- W2077993168 cites W2037341321 @default.
- W2077993168 cites W2037495834 @default.
- W2077993168 cites W2037688283 @default.
- W2077993168 cites W2041052894 @default.
- W2077993168 cites W2042179780 @default.
- W2077993168 cites W2044061154 @default.
- W2077993168 cites W2045120961 @default.