FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077994730> ?p ?o ?g. }

• W2077994730 abstract "Inflammatory basal ganglia disorders are infectious and autoimmune conditions presenting with movement disorders and psychiatric symptoms. Autoimmune basal ganglia disorders (ABGA) include Sydenham's chorea and recently described basal ganglia encephalitis associated with autoantibody against dopamine D2 receptor. Although autoantibodies are implicated in the pathogenesis of ABGA, the presence of seronegative cases suggests their etiological diversity. To elucidate the immune mechanisms of pediatric ABGA, we retrospectively analyzed clinical and neuroradiological data of patients with acute-onset inflammatory basal ganglia disorders and studied immunological markers in sera and CSF. Fourteen patients (11 males) aged between 8 months to 13 years were enrolled. Initial presentation was preceded by streptococcal infection in 5 cases. Clinical manifestations included chorea (n = 7), dystonia (n = 6), oral dyskinesia (n = 5), psychiatric symptoms (n = 7), and seizures (n = 9). Eleven showed magnetic resonance image signal abnormalities in basal ganglia. Moderate cerebrospinal fluid (CSF) pleocytosis (more than 50 cells per microliter) was found in 4 patients. Cytokines (interferon gamma, interleukin (IL)-6, IL-10, IL-12p70, tumor necrosis factor alpha) and chemokines (CCL2, CCL4, CXCL8, CXCL9, CXCL10) were measured in sera and CSF obtained from 9 patients. They were divided into two groups according to the presence of CSF pleocytosis: pleocytosis-positive (P group, n = 4) and -negative (N group, n = 5). Serum CCL4 level was significantly higher in N group than in P group (P b 0.05) and CSF IL-6 was significantly higher in P group than in N group (P b 0.05). CSF to serum ratio of CXCL9 and CXCL10 were significantly higher in P group than in N group (P b 0.05). Antineuronal antibodies tested by immunocytochemistry using rat primary neuronal culture detected antibodies against dendrite (n = 5), soma (n = 3), and nuclei (n = 5), with similar frequency between two groups. These results suggest that intracerebral inflammation generates chemokine gradient to recruit leukocytes into the brain in P group, whereas inflammation predominantly occurs systemically in N group." @default.
• W2077994730 created "2016-06-24" @default.
• W2077994730 creator A5001463703 @default.
• W2077994730 creator A5003676849 @default.
• W2077994730 creator A5019222690 @default.
• W2077994730 creator A5028837006 @default.
• W2077994730 creator A5031234812 @default.
• W2077994730 creator A5063884424 @default.
• W2077994730 creator A5068802667 @default.
• W2077994730 creator A5070466559 @default.
• W2077994730 creator A5076830613 @default.
• W2077994730 date "2014-10-01" @default.
• W2077994730 modified "2023-09-27" @default.
• W2077994730 title "A dual role for fibroblast growth factor 9 in multiple sclerosis: Inhibition of (re)myelination and induction of pro-inflammatory environment" @default.
• W2077994730 doi "https://doi.org/10.1016/j.jneuroim.2014.08.289" @default.
• W2077994730 hasPublicationYear "2014" @default.
• W2077994730 type Work @default.
• W2077994730 sameAs 2077994730 @default.
• W2077994730 citedByCount "0" @default.
• W2077994730 crossrefType "journal-article" @default.
• W2077994730 hasAuthorship W2077994730A5001463703 @default.
• W2077994730 hasAuthorship W2077994730A5003676849 @default.
• W2077994730 hasAuthorship W2077994730A5019222690 @default.
• W2077994730 hasAuthorship W2077994730A5028837006 @default.
• W2077994730 hasAuthorship W2077994730A5031234812 @default.
• W2077994730 hasAuthorship W2077994730A5063884424 @default.
• W2077994730 hasAuthorship W2077994730A5068802667 @default.
• W2077994730 hasAuthorship W2077994730A5070466559 @default.
• W2077994730 hasAuthorship W2077994730A5076830613 @default.
• W2077994730 hasConcept C126322002 @default.
• W2077994730 hasConcept C142724271 @default.
• W2077994730 hasConcept C203014093 @default.
• W2077994730 hasConcept C2777483564 @default.
• W2077994730 hasConcept C2778868616 @default.
• W2077994730 hasConcept C2779134260 @default.
• W2077994730 hasConcept C2779651940 @default.
• W2077994730 hasConcept C2909292722 @default.
• W2077994730 hasConcept C71924100 @default.
• W2077994730 hasConcept C90924648 @default.
• W2077994730 hasConceptScore W2077994730C126322002 @default.
• W2077994730 hasConceptScore W2077994730C142724271 @default.
• W2077994730 hasConceptScore W2077994730C203014093 @default.
• W2077994730 hasConceptScore W2077994730C2777483564 @default.
• W2077994730 hasConceptScore W2077994730C2778868616 @default.
• W2077994730 hasConceptScore W2077994730C2779134260 @default.
• W2077994730 hasConceptScore W2077994730C2779651940 @default.
• W2077994730 hasConceptScore W2077994730C2909292722 @default.
• W2077994730 hasConceptScore W2077994730C71924100 @default.
• W2077994730 hasConceptScore W2077994730C90924648 @default.
• W2077994730 hasLocation W20779947301 @default.
• W2077994730 hasOpenAccess W2077994730 @default.
• W2077994730 hasPrimaryLocation W20779947301 @default.
• W2077994730 hasRelatedWork W1506399484 @default.
• W2077994730 hasRelatedWork W1934191417 @default.
• W2077994730 hasRelatedWork W1991821580 @default.
• W2077994730 hasRelatedWork W2017854040 @default.
• W2077994730 hasRelatedWork W2026571295 @default.
• W2077994730 hasRelatedWork W2086342486 @default.
• W2077994730 hasRelatedWork W2102071302 @default.
• W2077994730 hasRelatedWork W2152770320 @default.
• W2077994730 hasRelatedWork W2371651744 @default.
• W2077994730 hasRelatedWork W2388948358 @default.
• W2077994730 hasRelatedWork W2391645700 @default.
• W2077994730 hasRelatedWork W2417596986 @default.
• W2077994730 hasRelatedWork W2526957115 @default.
• W2077994730 hasRelatedWork W2564166913 @default.
• W2077994730 hasRelatedWork W2574615563 @default.
• W2077994730 hasRelatedWork W2972912892 @default.
• W2077994730 hasRelatedWork W2991160438 @default.
• W2077994730 hasRelatedWork W3028846495 @default.
• W2077994730 hasRelatedWork W3070885881 @default.
• W2077994730 hasRelatedWork W3093132443 @default.
• W2077994730 isParatext "false" @default.
• W2077994730 isRetracted "false" @default.
• W2077994730 magId "2077994730" @default.
• W2077994730 workType "article" @default.