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- W2077996468 abstract "Background/Aim: Prostaglandins (PGs), widely distributed in the human and animal gastrointestinal tract, play important roles in cytoprotection, secretion and absorbtion, and motility of the digestive tract. However, their effects on the biliary tract are not well studied. The aim of the present study is to investigate effects of PGs E1 and F2a on motility of the human sphincter of Oddi (SO). Methods: Twenty-seven patients appearing for routine endoscopic retrograde cholangiopancreatography (ERCP) were studied. Each patient was randomly allocated to receive an intravenous infusion of normal saline (six patients), alprostadil alfadex, a synthetic PGE1 analogue, at a dose of either 0.05 or 0.1 μg/kg/min (seven patients for each condition), or dinoprost, a synthetic PGF2α analogue, at a dose of 1.0 μg/kg/min (seven patients). Endoscopic biliary manometry was done with a recording of basal SO pressure (mmHg), SO phasic wave amplitude (mmHg) and frequency (/min) before and 5 min after intravenous infusions, using a 4 Fr microtransducer catheter (Galtec Ltd). Values are reported as the mean±SEM. Paired Student's t tests were used to compare variables before and after injection. Differences with p values of less than 0.05 were considered significant. Results: There was no significant change in SO motor variables following application of normal saline. Alprostadil alfadex significantly decreased basal SO pressure and SO phasic wave frequency at a dose of 0.05 μg/kg/min and significantly decreased all parameters at a dose of 0.1 μg/kg/min, while dinoprost significantly increased only SO phasic wave frequency. Conclusion: A synthetic PGE1 analogue, alprostadil alfadex, has an inhibitory effect on motility of the human SO.This drug may be applicable to clinical use as a SO relaxing agent." @default.
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- W2077996468 date "2000-04-01" @default.
- W2077996468 modified "2023-09-27" @default.
- W2077996468 title "6998 Effects of synthetic prostaglandins e1 and f2a on motility of the sphincter of oddi in humans." @default.
- W2077996468 doi "https://doi.org/10.1016/s0016-5107(00)14669-3" @default.
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